Development of new well-defined multifunctional dendrimers for applications in nanomedicine

• Grant number: 15/23761-2
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2016
• End date: February 28, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Cátia Cristina Capêlo Ornelas Megiatto
• Grantee: Cátia Cristina Capêlo Ornelas Megiatto
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Dendrimers are well-defined branched macromolecules that are built in a stepwise manner, which are accepted as being a special class of polymers with a monodisperse architecture. The goal of the current project is the development of new biocompatible multifunctional nanomaterials based on well-defined multifunctional dendrimers, for application in nanomedicine. The project will focus on the synthesis of the new materials using innovative synthetic strategies based on orthogonality and click chemistry. The new dendrimers will be functionalized at specific locations with drugs, imaging agents, and/or targeting groups. The cytotoxicity of the new nanomaterials will be tested against several cell lines in order to define if these materials are valid candidates for drug delivery platforms. These materials will also be explored as multivalent platforms for SPR and electrochemical biosensors. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GARZON-PORRAS, ANA M.; BERTUZZI, DIEGO L.; LUCAS, KURT; DA SILVA, LAURA C. E.; DE OLIVEIRA, MARCELO G.; ORNELAS, CATIA. Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity. ACS APPLIED POLYMER MATERIALS, v. 2, n. 5, p. 2027-2034, MAY 2020. (18/14142-5, 18/02093-0, 15/23761-2, 15/04929-0, 16/02414-5)

ALCANTARA, ARTHUR F. P.; FONTANA, LINIQUER A.; ALMEIDA, MARLON P.; RIGOLIN, VITOR H.; RIBEIRO, MARCOS A.; BARROS, WDESON P.; MEGIATTO, JR., JACKSON D.. Control over the Redox Cooperative Mechanism of Radical Carbene Transfer Reactions for the Efficient Active-Metal-Template Synthesis of [2]Rotaxanes. CHEMISTRY-A EUROPEAN JOURNAL, v. 26, n. 35, p. 7808-7822, JUN 23 2020. (17/06752-5, 15/23761-2, 13/22160-0)

FONTANA, LINIQUER A.; ALMEIDA, MARLON P.; ALCANTARA, ARTHUR F. P.; RIGOLIN, VITOR H.; RIBEIRO, MARCOS A.; BARROS, WDESON P.; MEGIATTO, JACKSON D.. Ru(II)Porphyrinate-based molecular nanoreactor for carbene insertion reactions and quantitative formation of rotaxanes by active-metal-template syntheses. NATURE COMMUNICATIONS, v. 11, n. 1, DEC 11 2020. (17/06752-5, 13/22160-0, 15/23761-2)

ALCANTARA, ARTHUR F. P.; FONTANA, LINIQUER A.; RIGOLIN, VITOR H.; ANDRADE, YURI F. S.; RIBEIRO, MARCOS A.; BARROS, WDESON P.; ORNELAS, CATIA; MEGIATTO, JR., JACKSON D.. Olefin Cyclopropanation by Radical Carbene Transfer Reactions Promoted by Cobalt(II)/Porphyrinates: Active-Metal-Template Synthesis of [2]Rotaxanes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 57, n. 29, p. 8979-8983, JUL 16 2018. (15/23761-2, 13/22160-0, 15/22379-7, 17/06752-5)

GARZON-PORRAS, ANA M.; BERTUZZI, DIEGO L.; LUCAS, KURT; DA SILVA, LAURA C. E.; DE OLIVEIRA, MARCELO G.; ORNELAS, CATIA. Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity. ACS APPLIED POLYMER MATERIALS, v. 2, n. 5, p. 8-pg., 2020-05-01. (18/02093-0, 15/04929-0, 18/14142-5, 15/23761-2, 16/02414-5)