| Grant number: | 15/17321-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2016 |
| End date: | January 31, 2018 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Alessandra Carvalho Goulart |
| Grantee: | Alessandra Carvalho Goulart |
| Host Institution: | Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated researchers: | Adriana Bastos Conforto ; Alessandra Fernandes Baccaro ; Andre Russowsky Brunoni ; Claudia da Costa Leite ; Geraldo Busatto Filho ; Isabela Judith Martins Bensenor ; Itamar de Souza Santos ; Paulo Andrade Lotufo ; Wang Yuan Pang |
Abstract
Recent data shows that stroke is responsible for about 5.7 million deaths, of which 87% have been reported in countries with low and middle incomes. In Brazil, the stroke in association with hypertension was responsible for the occurrence of 52,000 deaths in 2012, and ranked as the third cause of mortality. The reported risk of death by stroke is two times higher in areas with low income status (SES) compared to areas with higher SES in São Paulo. Despite the impact of cerebrovascular disease as a major public health problem, few resources have been used in strategies to control risk factors, organization of public networks of medical care, and especially rehabilitation and support of patients affected by stroke. In addition to the physical and motor limitations, the patient post-stroke, can often develop neuropsychological changes as depressive symptoms and cognitive impairment that may progress to severe depression and dementia. It is estimated that the post-stroke depression can occur in around 30-50% of cases and is usually associated with a worsening of cognitive status, impaired recovery of motor function and increased mortality. In addition, post-stroke depression is also associated with a deterioration in the quality life. Therefore, we propose an extended evaluation in a sub-sample of prospective cohort of the EMMA study (Mortality and Morbidity Study of Stroke), which provides for monitoring the evolution of depression and cognitive impairment after stroke, and prognostic value of neuroimaging and biomarkers related to vascular injury in long term survival. (AU)
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