Proteomic analysis of evolutionary stages from Strongyloides venezuelensis

• Grant number: 16/06185-0
• Support Opportunities: Regular Research Grants
• Field of knowledge: Biological Sciences - Parasitology - Helminthology of Parasites
• Principal Investigator: Fabiana Martins de Paula
• Grantee: Fabiana Martins de Paula
• Host Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Julia Maria Costa Cruz ; Marcelo Andreetta Corral ; Maria Cristina Carvalho Do Espírito Santo ; Priscilla Duarte Marques Fonseca ; Ronaldo Cesar Borges Cryschek ; William de Castro Borges
• Associated scholarship(s): 18/06129-9 - Maintenance of evolutionary stages of Strongyloides venezuelensis, BP.TT

Abstract

The strongyloidiasis is a parasitic disease caused by the nematode Strongyloides stercoralis. This helminths can take extreme gravity, culminating in death, especially in immunocompromised patients. Increasingly it has used Strongyloides venezuelensis species as an alternative for the production of antigens, in addition to studies on aspects of host-parasite relationship. Using proteomics, this study to evaluate the expression of proteins in different developmental stages from S. venezuelensis, and identify immunogenic proteins filariform larvae of S. venezuelensis recognized by anibodies presente in serum samples from experimentally infected rats. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROLDAN, W. H.; MARTINS DE PAULA, F.; GRYSCHEK, R. C. B.. A simple method for purification of Strongyloides venezuelensis eggs from rat faeces. JOURNAL OF HELMINTHOLOGY, v. 94, NOV 18 2020. (16/06185-0)

FONSECA, PRISCILLA D. M.; CORRAL, MARCELO A.; COSENZA-CONTRERAS, MIGUEL; MEISEL, DIRCE M. C. L.; MELO, GESSICA B.; ANTUNES, MILENA M. S.; SANTO, MARIA C. E.; GRYSCHEK, RONALDO C. B.; COSTA-CRUZ, JULIA M.; CASTRO-BORGES, WILLIAM; et al. Shotgun proteomics of Strongyloides venezuelensis infective third stage larvae: Insights into host-parasite interaction and novel targets for diagnostics. Molecular and Biochemical Parasitology, v. 235, JAN 2020. (16/06185-0)

PRISCILLA DUARTE MARQUES FONSECA; MARCELO ANDREETA CORRAL; DIRCE MARY C. LIMA MEISEL; DEBORA LEVI; RAFAEL CORREA NASCIMENTO; WILLIAM CASTRO-BORGES; RONALDO GRYSCHEK; JULIA MARIA COSTA-CRUZ; FABIANA MARTINS DE PAULA. Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis. Revista do Instituto de Medicina Tropical de São Paulo, v. 62, 2020-05-11. (16/06185-0)

NASCIMENTO, RAFAEL C.; MELO, GESSICA B.; FONSECA, PRISCILLA D. M.; GRYSCHEK, RONALDO C. B.; PAULA, F. M.. Evaluation of targets for Strongyloides genus specific molecular diagnosis in experimental strongyloidiasis. Experimental Parasitology, v. 230, NOV 2021. (16/06185-0)