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Behavior and muscle biomarkers in rats submitted to overtraining syndrome

Grant number: 15/26738-1
Support type:Regular Research Grants
Duration: October 01, 2016 - March 31, 2019
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Guilherme de Camargo Ferraz
Grantee:Guilherme de Camargo Ferraz
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Assoc. researchers:Eliana Gertrudes de Macedo Lemos


The overtraining syndrome (OS) reduces the performance of human and equine athletes. It is caused by an imbalance between training sessions and recovery periods. Some studies have used rodents to study the OS and the syndrome may be associated with behavioral, neuroendocrine, and metabolic disorders. Despite the high prevalence in athletes, there are few clinical and laboratory tests available for the prevention and diagnosis of OS. This study proposes to investigate (1) the behavior and (2) muscle biomarkes in Wistar rats that have been experimentally induced to OS on a treadmill. One hundred young male rats weighing between 150 and 250g will be used. The animals are going to be distributed in the control groups (CT), trained (TR), high performance (AD) and low performance (BD). The duration of the OS induction protocol will be 11 weeks distributed in 5 phases. Phases 1 and 2 will consist of a single daily workout. Subsequently, the following phases will consist of increased training intensity and reduced recovery time. Performance tests will be conducted before the training and after the 4th, 8th, 9th, 10th and 11th weeks. Two additional performance tests will be conducted in the weeks of recovery. Rats will be subjected to behavioral tests such as open field and elevated plus maze. Plasma corticosterone and lactate measurements will be performed. Muscle and cardiac biomarkers such as myoglobin, creatine kinase, aspartate aminotransferase, CK-MB and expression of the MCT4 and MCT1 isoforms will also be quantified. For all possible comparisons, the analysis of variance (ANOVA) and the paired and unpaired "Student" t test will be used as needed. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RESTAN, ALEJANDRO Z.; CAMACHO, APARECIDO A.; CERQUEIRA, JULIANA A.; ZACCHE, EVANDRO; KIRNEW, MURILLO D.; LOUREIRO, BRUNA A.; SILVA, SAMARA B.; MORANZA, HENRIETTE G.; FERRAZ, GUILHERME C. Effect of a lactate-guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs. PLoS One, v. 15, n. 6 JUN 1 2020. Web of Science Citations: 0.
ESTEVES TRINDADE, PEDRO HENRIQUE; HARTMANN, ELKE; KEELING, LINDA J.; ANDERSEN, PIA HAUBRO; FERRAZ, GUILHERME DE CAMARGO; RODRIGUES PARANHOS DA COSTA, MATEUS JOSE. Effect of work on body language of ranch horses in Brazil. PLoS One, v. 15, n. 1 JAN 28 2020. Web of Science Citations: 1.
CARVALHO, JULIA R. G.; CONDE, GABRIEL; ANTONIOLI, MARINA L.; DIAS, PAULA P.; VASCONCELOS, ROSEMERI O.; TABOGA, SEBASTIAO R.; CANOLA, PAULO A.; CHINELATTO, MARCELO A.; PEREIRA, GENER T.; FERRAZ, GUILHERME C. Biocompatibility and biodegradation of poly(lactic acid) (PLA) and an immiscible PLA/poly(epsilon-caprolactone) (PCL) blend compatibilized by poly(epsilon-caprolactone-b-tetrahydrofuran) implanted in horses. POLYMER JOURNAL, v. 52, n. 6 JAN 2020. Web of Science Citations: 0.

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