Inflammatory cytokines and BDNF response to high-intensity intermittent exercise: effect the exercise volume

• Grant number: 16/20906-2
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: November 01, 2016
• End date: April 30, 2017
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Fábio Santos de Lira
• Grantee: Fábio Santos de Lira
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

The purpose of this study was to compare the effects of two similar high-intensity intermittent exercises (HIIE) but different volume 1.25km (HIIE1.25) and 2.5km (HIIE2.5) and therefore different effects on inflammatory and BDNF responses. Ten physically active male subjects (age 25.22±1.74years, body mass 78.98±7.31kg, height 1.78±0.06m, VO2peak 59.94±9.38ml*kg*min-1) performed an incremental treadmill exercise test and completed two randomly sessions of HIIE on a treadmill (1:1 min at vVO2max with passive recovery). Blood samples were collected at rest, immediately and 60-minutes after exercise sessions. Serum was analysed for glucose, lactate, IL-6, IL-10 and BDNF levels. The lactate levels exhibited higher values immediately post-exercise than at rest (HIIE1.25: 1.69±0.26 to 7.78±2.09mmol*L-1, and HIIE2.5: 1.89±0.26 to 7.38±2.57mmol*L-1, p<0.0001). Glucose concentrations did not present changes under the different conditions, however, levels were higher 60-min post-exercise than at rest only in the HIIE1.25 condition (rest: 76.80±11.14 to 97.84±24.87mg*dL-1, p<0.05). BDNF level increased immediately after exercise in both protocol (HIIE1.25: 9.71±306 to 17.86±8.59ng/mL, and HIIE2.5: 11.83±5.82 to 22.84±10.30ng/mL). Although both exercises increased IL-6, level increase percentage between rest and immediately after exercise was higher in the HIIE2.5 than HIIE1.25 (30% and 10%; p=0.014, respectively). Moreover, IL-10 levels increase percentage between immediately and 60-min post-exercise was higher in HIIE2.5 than HIIE1.25 (37% and 10%; p=0.012, respectively). In conclusion, both HIIE protocols are effective to increase BDNF and IL-6 levels immediately after exercise while IL-10 time-response depends on the volume. (AU)