Use of residual extract of Artemisia annua L., resulting from the extraction of antimalarial sesquiterpene in cosmetic applications

• Grant number: 16/10639-7
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: November 01, 2016
• End date: October 31, 2018
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Rosana Maria Alberici Oliveira
• Grantee: Rosana Maria Alberici Oliveira
• Company: Soraya El Khatib - EPP
• City: Campinas
• Pesquisadores principais: Marcos Nogueira Eberlin ; Maria Angela de Almeida Meireles Petenate
• Associated researchers: Daniel Barrera Arellano ; Gislaine Chrystina Nogueira de Faria ; Mary Ann Foglio ; Renata Vardanega
• Associated research grant: 14/21549-3 - Use of residual extract of Artemisia annua L., resulting from the extraction of antimalarial sesquiterpene in cosmetic applications, AP.PIPE
• Associated research grant(s): 17/14355-6 - Artemisia annua L. volatile oil obtained by pressurized CO2 extraction: potential application in cosmetics with insect-repellent properties, AP.PIPE
• Associated scholarship(s): 18/02833-3 - Utilization of residual extract of Artemisia annua L., resulting from the extraction of antimalarial sesquiterpene, in cosmetic applications, BP.TT; 16/22630-4 - Use of residual extract of Artemisia annua L., resulting from the extraction of antimalarial sesquiterpene, in cosmetic applications, BP.PIPE

Abstract

Artemisia annua L., a plant species naturally occurring in China and Vietnam, have been widely used in the treatment of malaria. Among the secondary metabolites isolated from Artemisia species, the most characteristic are the sesquiterpene lactones, and artemisinin (quinghaosu) (1.2%/p), which shows effectiveness in the treatment of malaria caused by Plasmodium falciparum. The species is the only economically viable source of this molecule. In Brazil, the cultivation of A. annua was adapted to the climatic conditions in southeastern Brazil by The Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA-Unicamp). In the production process of this important anti-malarial is generated a significant extracting residue with high pharmacological activity such as anti-inflammatory, antimicrobial and antioxidant properties that is obtained by technologies involving supercritical fluids, using as solvents harmless substances to the environment and human health, such as CO2, leading to obtaining extracts with different chemical composition, smoother and effective for use in cosmetics. The extracts will be standardized and validated using Spectrometry Mass. By this project, the S Cosméticos do Bem seeks to innovate by developing a new sustainable cosmetic product with therapeutic properties, efficacy and safety proven, highly competitive and has great economic potential, both in domestic and international markets. (AU)

Filed patent(s) as a result of this research project