Study of B lymphocytes subset in peripheral blood of patients with a primary progressive form of multiple sclerosis

• Grant number: 16/17404-5
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2016
• End date: January 31, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Leonilda Maria Barbosa dos Santos
• Grantee: Leonilda Maria Barbosa dos Santos
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

B lymphocytes actively participate in the pathogenesis of multiple sclerosis, mainly in the progressive forms of the disease. Autoantibodies can cause tissue damage in the neurons contributing to neurodegeneration. B lymphocytes are specific antigen-presenting cells, since neuroantigen is recognized by BCR and processed antigen is presented to CD4 autoreactive T cells. Furthermore, B-lymphocytes produce pro-inflammatory cytokines thus amplifying the inflammatory response. Moreover, tertiary lymphoid niches, rich in B-cells were identified in the meninges of MS patients with secondary progressive form of the disease. In this study, we aim to study the response of subpopulations of B lymphocytes (cytotoxic and suppressor) of patients with primary progressive MS. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMILO, DANIELA S.; PRADELLA, FERNANDO; PAULINO, MARIA FERNANDA; BARACAT, EMILIO C. E.; MARINI, SOFIA H.; GUERRA, JR., GIL; PAVIN, ELIZABETH J.; PARISI, CANDIDA; LONGHINI, ANA LEDA F.; MARQUES, SILVIA B.; et al. Partial remission in Brazilian children and adolescents with type 1 diabetes. Association with a haplotype of class II human leukocyte antigen and synthesis of autoantibodies. PEDIATRIC DIABETES, v. 21, n. 4, p. 606-614, JUN 2020. (12/24667-1, 16/17404-5, 13/12109-7, 12/04565-0)

TAUIL, C. B.; ROCHA-LIMA, A. D.; FERRARI, B. B.; SILVA, F. M.; MACHADO, L. A.; RAMARI, C.; BRANDAO, C. O.; DOS SANTOS, L. M. B.; DOS SANTOS-NETO, L. L.. Depression and anxiety disorders in patients with multiple sclerosis: association with neurodegeneration and neurofilaments. Brazilian Journal of Medical and Biological Research, v. 54, n. 3, 2021. (14/26431-0, 16/17404-5)

TAUIL, CARLOS B.; LIMA, AMANDA D. DA ROCHA; FERRARI, BRENO B.; DA SILVA, VERONICA A. G.; MORAES, ADRIEL S.; DA SILVA, FLAVIA M.; MELO-SILVA, CESAR A.; FARIAS, ALESSANDRO S.; BRANDA, CARLOS O.; LEONILDA, M. B. DOSSANTOS; et al. Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod: Role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines. BRAIN, BEHAVIOR, & IMMUNITY - HEALTH, v. 9, p. 7-pg., 2020-12-01. (14/26431-0, 16/17404-5)