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The relationship between maternal psychological factors and glycaemic profile and adiposity of the offspring

Grant number: 16/13684-3
Support type:Regular Research Grants
Duration: December 01, 2016 - November 30, 2018
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Patricia Helen de Carvalho Rondó
Grantee:Patricia Helen de Carvalho Rondó
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Gizelton Pereira Alencar

Abstract

Introduction: Insulin resistance in pregnancy may be associated to adiposity of the offspring by inflammatory mechanisms triggered by stress and distress, involving the hyperactivity of the hypothalamic-pituitary-adrenal axis. Objective: To evaluate the relationship between psychological factors and glycemic profile of pregnant women and adiposity of the respective neonates. Methods: Prospective cohort study to be carried out in 31 health units, Gota de Leite Maternity and Serviço Especial de Saúde de Araraquara, involving 700 pregnant women with gestational age lower or equal 12 weeks, who will be followed in the three trimesters of pregnancy to the birth of their babies. Maternal stress and distress will be evaluated by the following instruments: General Health Questionnaire, Edinburgh Postnatal Depression Scale, State-Trait Anxiety Inventory, and Perceived Stress Scale. Fasting glucose and insulin, and C-reactive protein will be determined respectively by enzymatic UV test with hexokinase, chemiluminescence and immunoturbidimetry. Body composition of the pregnant women will be evaluated quarterly by electrical bioimpedance-BIA (Inbody 370, Biospace®, Korea), validated by stable isotope. The body composition of the neonates will be assessed by plethysmography (PEA POD®, Cosmed, USA). In the statistical analysis the Chi-square test with Yates correction will be used for categorical variables, and the Student t test and Mann-Whitney test to compare pairs of values of the independent variables. The relationship between maternal psychological factors and glycemic profile and adiposity of the offspring will be evaluated by multiple regression analysis, controlling for confounders. (AU)