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The relationship between maternal adiposity and adiposity of the offspring in the fetal, neonatal and infant periods: a prospective population-based study

Grant number: 15/03333-6
Support type:Research Projects - Thematic Grants
Duration: October 01, 2016 - September 30, 2023
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal researcher:Patricia Helen de Carvalho Rondó
Grantee:Patricia Helen de Carvalho Rondó
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Alexandra Ivo de Medeiros ; Gizelton Pereira Alencar ; Jonathan Wells ; Philip Newsholme
Associated grant(s):19/07717-4 - Multiuser equipment approved in grant 2015/03333-6: bioimpedance ImpediMed ImpTM SFB7, AP.EMU
Associated scholarship(s):22/11670-6 - The association between diet and vaginal microbiota throughout pregnancy., BP.IC
22/04340-0 - The relationship between the maternal nutritional status and fetal body composition, BP.TT
22/02204-1 - The relationship between the nutritional status and lipid profile of children, BP.TT
+ associated scholarships 22/00793-0 - The relationship between the nutritional status and glycemic profile of children, BP.TT
20/15365-8 - The association between vaginal microbiota in pregnancy with infant gut microbiota and fetal and infant adiposity, BP.PD
18/17824-0 - DNA metilation profile of mother-concept binomy in the context of Maternal Obesity and fetal and neonatal adiposity, BP.DR
19/03764-8 - Prevalence of anemia in women at the first trimester of pregnancy, BP.TT
18/13468-4 - The relationship between maternal and fetal fatness in healthy women and women with gestational diabetes mellitus: a prospective, population-based cohort study in Araraquara, SP, BP.PD
18/10950-0 - Obstetric history of the pregnant women attended at the Basic Health Units of Araraquara city, SP, BP.TT
17/07143-2 - An immunological approach to the relationship between maternal and fetal adiposity in fetal, neonatal and infant periods, BP.PD - associated scholarships

Abstract

The obesity worldwide pandemic shows the need to investigate the factors involved in the early onset of the disease, still in uterus. This original population-based prospective cohort study aims to assess the nutritional status, body composition and metabolic factors of women in the 3 trimesters of pregnancy and relate to the fatness of their fetus, newborn and infant in the first year of life. The inflammatory/immunologic status of the women will be investigated in a sub-sample, by an innovative ex-vivo approach, as well as gene expression. Two thousand (2000) women with less or equal 12 weeks of gestational age attending antenatal care at 31 Health Care Units in Araraquara, SP, will be followed in the 3 trimesters of pregnancy until delivery. Later, their children will be seen every 3 months up to 1 year of age. Maternal nutritional status and adiposity will be investigated respectively, by BMI and segmented bioelectrical impedance, validated by stable isotope analysis. To assess the body composition of the fetus, newborn and infant with 1 year of age, the following methods will be used, respectively: ultrasound, plethysmography and dual-energy X-ray absorptiometry. Hematological, glycemic, lipid and inflammatory/immune profiles will be evaluated by blood count, glucose, insulin, HOMA-IR, glycated hemoglobin, total cholesterol/ fractions, triglycerides, apo-A1, apo-B, hsCRP, and cytokines in maternal blood, umbilical cord blood and/or child's blood. Gene expression will be determined by micro-array. The impact of the maternal factors investigated on adiposity of the fetus, newborn and child will be assessed by multiple linear regression and by new methods for analysis of longitudinal data and multivariate modeling. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAKANDAKARE, P.; NICOLETTI, C. F.; NORONHA, N. Y.; NONINO, C. B.; ARGENTATO, P. P.; DEJANI, N. N.; LUZIA, L. A.; ROGERO, M. M.; RONDO, P. H. C.. Associations between obesity-related gene expression in maternal and cord blood and newborn adiposity: findings from the Araraquara Cohort study. International Journal of Obesity, v. 45, n. 9, p. 1958-1966, . (18/17824-0, 17/07143-2, 15/03333-6)

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