The relationship between maternal adiposity and adiposity of the offspring in the fetal, neonatal and infant periods: a prospective population-based study

• Grant number: 15/03333-6
• Support Opportunities: Research Projects - Thematic Grants
• Duration: October 01, 2016 - September 30, 2024
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal Investigator: Patricia Helen de Carvalho Rondó
• Grantee: Patricia Helen de Carvalho Rondó
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Alexandra Ivo de Medeiros ; Gizelton Pereira Alencar ; Jonathan Wells ; Philip Newsholme
• Associated grant(s): 19/07717-4 - Multiuser equipment approved in grant 2015/03333-6: bioimpedance ImpediMed ImpTM SFB7, AP.EMU
• Associated scholarship(s): 24/01014-0 - The relationship between serum vitamin D concentrations and hypertensive disorders of pregnancy, BP.DR; 24/05132-7 - The relationship between the maternal nutritional status and fetal body composition, BP.TT; 23/07936-3 - The influence of gestational weight gain on fetal growth and neonatal outcomes: Araraquara Cohort Study., BP.DR; + associated scholarships 23/07757-1 - The relationship between the nutritional status and glycemic profile of children, BP.TT; 23/02404-3 - Pre-gestational overweight, fetal growth and adiposity, BP.MS; 22/11670-6 - The association between diet and vaginal microbiota throughout pregnancy., BP.IC; 22/04340-0 - The relationship between the maternal nutritional status and fetal body composition, BP.TT; 22/02204-1 - The relationship between the nutritional status and lipid profile of children, BP.TT; 22/00793-0 - The relationship between the nutritional status and glycemic profile of children, BP.TT; 20/15365-8 - The association between vaginal microbiota in pregnancy with infant gut microbiota and fetal and infant adiposity, BP.PD; 18/17824-0 - DNA metilation profile of mother-concept binomy in the context of Maternal Obesity and fetal and neonatal adiposity, BP.DR; 19/03764-8 - Prevalence of anemia in women at the first trimester of pregnancy, BP.TT; 18/13468-4 - The relationship between maternal and fetal fatness in healthy women and women with gestational diabetes mellitus: a prospective, population-based cohort study in Araraquara, SP, BP.PD; 18/10950-0 - Obstetric history of the pregnant women attended at the Basic Health Units of Araraquara city, SP, BP.TT; 17/07143-2 - An immunological approach to the relationship between maternal and fetal adiposity in fetal, neonatal and infant periods, BP.PD - associated scholarships

Abstract

The obesity worldwide pandemic shows the need to investigate the factors involved in the early onset of the disease, still in uterus. This original population-based prospective cohort study aims to assess the nutritional status, body composition and metabolic factors of women in the 3 trimesters of pregnancy and relate to the fatness of their fetus, newborn and infant in the first year of life. The inflammatory/immunologic status of the women will be investigated in a sub-sample, by an innovative ex-vivo approach, as well as gene expression. Two thousand (2000) women with less or equal 12 weeks of gestational age attending antenatal care at 31 Health Care Units in Araraquara, SP, will be followed in the 3 trimesters of pregnancy until delivery. Later, their children will be seen every 3 months up to 1 year of age. Maternal nutritional status and adiposity will be investigated respectively, by BMI and segmented bioelectrical impedance, validated by stable isotope analysis. To assess the body composition of the fetus, newborn and infant with 1 year of age, the following methods will be used, respectively: ultrasound, plethysmography and dual-energy X-ray absorptiometry. Hematological, glycemic, lipid and inflammatory/immune profiles will be evaluated by blood count, glucose, insulin, HOMA-IR, glycated hemoglobin, total cholesterol/ fractions, triglycerides, apo-A1, apo-B, hsCRP, and cytokines in maternal blood, umbilical cord blood and/or child's blood. Gene expression will be determined by micro-array. The impact of the maternal factors investigated on adiposity of the fetus, newborn and child will be assessed by multiple linear regression and by new methods for analysis of longitudinal data and multivariate modeling. (AU)

Publicações científicas

(7)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

NAKANDAKARE, P.; NICOLETTI, C. F.; NORONHA, N. Y.; NONINO, C. B.; ARGENTATO, P. P.; DEJANI, N. N.; LUZIA, L. A.; ROGERO, M. M.; RONDO, P. H. C.. Associations between obesity-related gene expression in maternal and cord blood and newborn adiposity: findings from the Araraquara Cohort study. International Journal of Obesity, MAY 2021. (18/17824-0, 17/07143-2, 15/03333-6)

NAKANDAKARE, P.; NICOLETTI, C. F.; NORONHA, N. Y.; NONINO, C. B.; ARGENTATO, P. P.; DEJANI, N. N.; LUZIA, L. A.; ROGERO, M. M.; RONDO, P. H. C.. Associations between obesity-related gene expression in maternal and cord blood and newborn adiposity: findings from the Araraquara Cohort study. International Journal of Obesity, v. 45, n. 9, p. 1958-1966, SEP 2021. (18/17824-0, 17/07143-2, 15/03333-6)

PERLA PIZZI ARGENTATO; JOÃO VICTOR DA SILVA GUERRA; LIANIA ALVES LUZIA; ESTER SILVEIRA RAMOS; MARIANA MASCHIETTO; PATRÍCIA HELEN DE CARVALHO RONDÓ. Integrative network analysis of differentially methylated regions to study the impact of gestational weight gain on maternal metabolism and fetal-neonatal growth. GENETICS AND MOLECULAR BIOLOGY, v. 47, n. 1, 2024-03-25. (15/03333-6, 18/17824-0)

BRANCO, ANNA CLAUDIA CALVIELLI CASTELO; DE OLIVEIRA, EMILY ARAUJO; PEREIRA, NATALLI ZANETE; ALBERCA, RICARDO WESLEY; DUARTE-NETO, AMARO NUNES; DA SILVA, LUIZ FERNANDO FERRAZ; LUIZ, FERNANDA GUEDES; PEREIRA, NAIURA VIEIRA; SOTTO, MIRIAN NACAGAMI; DEJANI, NAIARA NAIANA; et al. Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus. Viruses-Basel, v. 15, n. 2, p. 15-pg., 2023-02-01. (15/03333-6, 19/26928-6, 19/25119-7, 17/07143-2)

NAIARA NAIANA DEJANI; CAROLINA F. NICOLETTI; PERLA PIZZI ARGENTATO; LUDMILLA DA SILVA PEREIRA; AMANDA CORREIA SARAIVA; LETÍCIA MONTANHA DE ASSIS; PATRÍCIA YURY NAKANDAKARE; LÍVIA PATRICIA RODRIGUES BATISTA; LAÍSLA DE FRANÇA DA SILVA TELES; MARIA PAULA LEITÃO; et al. Maternal plasma transforming growth factor-β1 (TGF-β1) and newborn size: the Araraquara Cohort Study. Jornal de Pediatria, v. 99, n. 3, p. 284-288, 2023-06-16. (15/03333-6, 18/17824-0, 17/07143-2, 18/19638-9)

DEJANI, NAIARA NAIANA; NICOLETTI, CAROLINA F.; ARGENTATO, PERLA PIZZI; PEREIRA, LUDMILLA DA SILVA; SARAIVA, AMANDA CORREIA; DE ASSIS, LETICIA MONTANHA; NAKANDAKARE, PATRICIA YURY; BATISTA, LIVIA PATRICIA RODRIGUES; TELES, LAISLA DE FRANCA DA SILVA; LEITAO, MARIA PAULA; et al. Maternal plasma transforming growth factor-b1 (TGF-b1) and newborn size: the Araraquara Cohort Study. Jornal de Pediatria, v. 99, n. 3, p. 5-pg., 2023-05-01. (15/03333-6, 18/17824-0, 18/19638-9, 17/07143-2)

ARGENTATO, PERLA PIZZI; MARCHESI, JORGE AUGUSTO PETROLI; DEJANI, NAIARA NAIANA; NAKANDAKARE, PATRICIA YURY; TELES, LAISLA DE FRANCA DA SILVA; BATISTA, LIVIA PATRICIA RODRIGUES; LEITAO, MARIA PAULA CARVALHO; LUZIA, LIANIA ALVES; RAMOS, ESTER SILVEIRA; RONDO, PATRICIA HELEN. The relationship between obesity-related H19DMR methylation and H19 and IGF2 gene expression on offspring growth and body composition. FRONTIERS IN NUTRITION, v. 10, p. 16-pg., 2023-09-21. (15/03333-6, 18/17824-0, 17/07143-2)