Characterization of cancer associated fibroblasts and its influence on canine neoplasms

• Grant number: 16/03862-1
• Support type: Regular Research Grants
• Duration: December 01, 2016 - May 31, 2019
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal researcher: Ricardo de Francisco Strefezzi
• Grantee: Ricardo de Francisco Strefezzi
• Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
• Assoc. researchers: Adriana Tomoko Nishiya ; Heidge Fukumasu ; Jose Luiz Catao Dias ; Maria Lucia Zaidan Dagli ; Silvio Henrique de Freitas

Abstract

Cancer is a complex tissue composed by malignant neoplastic cells surrounded by reactive stroma that contains fibroblasts, as well as inflammatory and endothelial cells, and whose dynamics is currently recognized as primordial for tumor evolution, grown and dissemination. It is believed that almost all solid tumors have atypical fibroblasts in their stromal compartment, known as cancer-associated fibroblasts (CAFs). Proteases secreted by CAFs are frequently positively regulated in tumoral microenvironment and influence neoplastic behavior through tissue architecture breakdown and signaling interactions. In dogs, mast cell tumor is one of the most frequent skin neoplasm and fibroblast are integral components of the connective tissue. These cells synthesize extracellular matrix components, including collagen, fibronectin and laminin, abundant in cutaneous microenvironment. The aim of this research project is to identify, isolate and characterize CAFs in canine mast cell tumors, and investigate their role in maintenance of tumors as dynamic entities and in the promotion of cancer invasive and metastatic potentials. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEITE, NATALIA GOULART; MORONI VARGAS, THIAGO HENRIQUE; FERRO, DANIEL GIBERNE; SOBRAL, RENATA AFONSO; FRANCOISE ANITA VENTURINI, MICHELE ALICE; CORREA, HERBERT LIMA; STREFEZZI, RICARDO DE FRANCISCO. Prognostic Value of Intratumoral Collagen Quantification in Canine Oral Melanomas. JOURNAL OF VETERINARY DENTISTRY, JAN 2022. Web of Science Citations: 0.

PULZ, LIDIA H.; CORDEIRO, YONARA G.; HUETE, GREICE C.; CADROBBI, KARINE G.; ROCHETTI, ARINA L.; XAVIER, PEDRO L. P.; NISHIYA, ADRIANA TOMOKO; DE FREITAS, SILVIO HENRIQUE; FUKUMASU, HEIDGE; STREFEZZI, RICARDO F. Intercellular interactions between mast cells and stromal fibroblasts obtained from canine cutaneous mast cell tumours. SCIENTIFIC REPORTS, v. 11, n. 1 DEC 13 2021. Web of Science Citations: 0.

VARGAS, THIAGO HENRIQUE M.; BARRA, CAMILA N.; PULZ, LIDIA H.; HUETE, GREICE C.; CADROBBI, KARINE G.; NISHIYA, ADRIANA TOMOKO; KLEEB, SILVIA REGINA; XAVIER, JOSE GUILHERME; CATAO-DIAS, JOSE LUIZ; STREFEZZI, RICARDO F. Galectin-3 immunolabelling correlates with BCL2 expression in canine cutaneous mast cell tumours. ACTA VETERINARIA HUNGARICA, v. 69, n. 2, p. 169-174, JUN 2021. Web of Science Citations: 0.

MARQUES, G. R.; ROCHA, L. F.; VARGAS, T. H. M.; PULZ, L. H.; HUETE, G. C.; CADROBBI, K. G.; PIRES, C. G.; SANCHES, D. S.; MOTA, E. F. F.; STREFEZZI, R. F. Relationship of Galectin-3 Expression in Canine Cutaneous Squamous Cell Carcinomas with Histopathological Grading and Proliferation Indices. Journal of Comparative Pathology, v. 178, p. 16-21, JUL 2020. Web of Science Citations: 0.

VARGAS, T. H. M.; PULZ, L. H.; FERRO, D. G.; SOBRAL, R. A.; VENTURINI, M. A. F. A.; CORREA, H. L.; STREFEZZI, R. F. Galectin-3 Expression Correlates with Post-surgical Survival in Canine Oral Melanomas. Journal of Comparative Pathology, v. 173, p. 49-57, NOV 2019. Web of Science Citations: 0.

DANIEL, JESSIKA; BARRA, CAMILA N.; PULZ, LIDIA H.; KLEEB, SILVIA REGINA; XAVIER, JOSE GUILHERME; CATAO-DIAS, JOSE LUIZ; NISHIYA, ADRIANA T.; FUKUMASU, HEIDGE; STREFEZZI, RICARDO F. Intratumoral collagen index predicts mortality and survival in canine cutaneous mast cell tumours. VETERINARY DERMATOLOGY, v. 30, n. 2, p. 162+, APR 2019. Web of Science Citations: 0.

JOSELEVITCH, JULIA A.; BARRA, CAMILA N.; VARGAS, THIAGO HENRIQUE M.; PULZ, LIDIA H.; NISHIYA, ADRIANA T.; KLEEB, SILVIA REGINA; XAVIER, JOSE GUILHERME; CATAO-DIAS, JOSE LUIZ; STREFEZZI, RICARDO F. Nanog Expression and Proliferation Indices in Canine Cutaneous Mast Cell Tumors. VETERINARY PATHOLOGY, v. 55, n. 6, p. 849-852, NOV 2018. Web of Science Citations: 0.

BARRA, C. N.; MACEDO, B. M.; CADROBBI, K. G.; PULZ, L. H.; HUETE, G. C.; KLEEB, S. R.; XAVIER, J. G.; CATAO-DIAS, J. L.; NISHIYA, A. T.; FUKUMASU, H.; STREFEZZI, R. F. Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours. VETERINARY AND COMPARATIVE ONCOLOGY, v. 16, n. 1, p. E38-E44, MAR 2018. Web of Science Citations: 2.