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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship of Galectin-3 Expression in Canine Cutaneous Squamous Cell Carcinomas with Histopathological Grading and Proliferation Indices

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Author(s):
Marques, G. R. [1] ; Rocha, L. F. [1] ; Vargas, T. H. M. [1] ; Pulz, L. H. [1, 2] ; Huete, G. C. [1, 3] ; Cadrobbi, K. G. [1, 3] ; Pires, C. G. [4] ; Sanches, D. S. [4] ; Mota, E. F. F. [5] ; Strefezzi, R. F. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Lab Oncol Comparada & Translac, Dept Med Vet, Fac Zootecnia & Engn Alimentos, Pirassununga - Brazil
[2] Ctr Univ Fundac Ensino Octavio Bastos, Sao Joao Da Boa Vista - Brazil
[3] PROVET Vet Diagnost, Sao Paulo - Brazil
[4] Ctr Vet Anat Patol CVAP, Sao Paulo - Brazil
[5] Histopet Patol Vet, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Comparative Pathology; v. 178, p. 16-21, JUL 2020.
Web of Science Citations: 0
Abstract

Squamous cell carcinoma (SCC) is a frequent malignant neoplasm of the skin that usually arises from areas of solar dermatosis. It is characterized by local invasiveness and regional lymph node metastasis, mainly in poorly differentiated tumours. Galectin-3 (Gal-3) is a lectin that is expressed in the nucleus or cytoplasm and has been identified as a prognostic tool for human neoplasms. The purpose of this study was to characterize Gal-3 expres-sion in canine cutaneous SCCs and to investigate its relationship with tumour differentiation and cell prolifer-ation indices. Immunohistochemical analysis of 50 SCCs for Gal-3 revealed no correlation between the localization or intensity of immunolabelling, or number of immunopositive cells, with histological grade of tumour or proliferative activity. The results suggest that Gal-3 expression is not a reliable prognostic marker for cutaneous SCC in dogs. (C) 2020 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/13252-8 - Characterization of apoptosis related genes in canine cutaneous mast cell tumors and its value as prognostic indicators
Grantee:Ricardo de Francisco Strefezzi
Support Opportunities: Regular Research Grants
FAPESP's process: 16/16239-0 - Galectin-3 expression as a prognostic factor for canine and feline squamous cell carcinoma
Grantee:Gabriela Ramos Marques
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/03862-1 - Characterization of cancer associated fibroblasts and its influence on canine neoplasms
Grantee:Ricardo de Francisco Strefezzi
Support Opportunities: Regular Research Grants