| Grant number: | 16/21470-3 |
| Support Opportunities: | Regular Research Grants |
| Start date: | March 01, 2017 |
| End date: | August 31, 2019 |
| Field of knowledge: | Biological Sciences - Biophysics - Molecular Biophysics |
| Principal Investigator: | Lionel Fernel Gamarra Contreras |
| Grantee: | Lionel Fernel Gamarra Contreras |
| Host Institution: | Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
| Associated researchers: | Alberto Tannús ; Dimas Tadeu Covas ; Fernando Fernandes Paiva ; Javier Bustamante Mamani ; Lucas Eduardo Botelho de Souza ; Luciana Cavalheiro Marti ; Rosalia Mendez-Otero |
Abstract
Type 2 diabetes mellitus (DM2) is a very prevalence disease and its incidence is increasing. About 8% of the Brazilian population is affected by this disease. Uncontrolled DM 2 increases the risk of cardiovascular and cerebrovascular disease by 75% in consequence of dyslipidemia and hypertension development and renal impairment. Previous studies indicate that cerebrovascular disorders, such as strokes, are major complications of DM2 causing great morbidity and mortality. Current research efforts focused on elucidating more specific and effective treatments for the regeneration of the ischemic area. Considering this background, the use of mesenchymal stem cells (MSC) in cellular therapy, especially in regenerative medicine, has emerged as a promising therapeutic tool. This kind of therapy approaches a variety of brain diseases owing to the MSC intrinsic capacity to self-renew and differentiate into multiple celllineages, including glial and neuronal cells, which facilitates their isolation, expansion, manipulation and modulation of the inflammatory response. Although the precise cellular and molecular mechanism involved in repair promoted by MSC in experimental studies remains a challenge, the literature clearly demonstrates the potential use of bone marrow cells in stroke models induced by DM2. Thus, this study intends to apply stem cells and nanobiotechnology combined with multifunctional magnetic nanoparticles and molecular imaging techniques to elucidate the mechanisms of treatment and contribute to the diagnosis, therapy and bioengineering advances in the biomedical field. The purpose of this project is to study the cellular and molecular mechanisms and functional repair mediated by MSC in the ischemic brain tissue marked with multimodal nanoparticles in animal models of DM2. The use of nanobiotechnological resources allow the monitorization of these cells in vivo by molecular images techniques, which tracks cells migration and assists thefunctional characterization of these cells in the ischemic brain region of the experimental modelinduced by photothrombosis. (AU)
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