Final vaginal axis in patients submitted to surgical prolapse correction - a randomized controlled trial

• Grant number: 16/24065-2
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2017
• End date: April 30, 2019
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Cássia Raquel Teatin Juliato
• Grantee: Cássia Raquel Teatin Juliato
• Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Luiz Carlos dos Santos Junior

Abstract

Female Pelvic Organ Prolapses (POP) are a great public health issue worldwide, with high and still rising incidences. Treatment is mostly surgical and the most popular procedures for the vaginal apex POP are: abdominal sacral colpopexy, considered as the gold-standard, and the vaginal sacrospinal colpopexy. Vaginal surgery for POP presents inferior results, despite being less morbid and cheaper when compared to the abdominal route, and the reason is still uncertain. One of the main theories is that the sacrospinal colpopexy could deviate normal vaginal axis. The main goal in this study is to compare post-operative vaginal axis between patients submitted to either vaginal sacrospinal colpopexy or abdominal sacral colpopexy, and its repercussion over anatomic results, urodynamic parameters and quality of life questionnaires. Patients and methods: 60 patients submitted to a pilot study comparing both colpopexy techniques using mesh (from 2014-2016), for stages 3-4 POP, will be invited to participate on a 1-year follow up revaluation through magnetic resonance, to show post-operative vaginal axis. Biometric and background relevant data, quality of life scores, post-operative subjective impression and POP-Q anatomic evaluations will be retracted from the subject's chart. Magnetic resonance interpretation will be done using the PICS system as a reference to determine post-operative vaginal axis. Statistical comparison between numeric variables will be done using correlation index or linear regression, while numeric and categorical variables will be done through Student' T test and Anova followed by Tukey. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS JUNIORS, LUIZ CARLOS; OLIVEIRA BRITO, LUIZ GUSTAVO; DE CASTRO, EDILSON BENEDITO; DERTKIGIL, SERGIO; TEATIN JULIATO, CASSIA RAQUEL. Mid- to Long-Term Magnetic Resonance Imaging Results of Two Prolapse Surgeries for Apical Defect: A Secondary Analysis of a Randomized Controlled Trial. Revista Brasileira de Ginecologia e Obstetrícia, v. 43, n. 1, p. 46-53, JAN 2021. (16/24065-2)

DE ARAUJO, CAMILA CARVALHO; COELHO, SUELENE A.; STAHLSCHMIDT, PAULO; JULIATO, CASSIA R. T.. Does vaginal delivery cause more damage to the pelvic floor than cesarean section as determined by 3D ultrasound evaluation? A systematic review. INTERNATIONAL UROGYNECOLOGY JOURNAL, v. 29, n. 5, p. 639-645, MAY 2018. (16/24065-2)