Characterization of osteogenic profile in bone defects with grafting submitted to therapy with low intensity electric current and magnetic electrostimulation

• Grant number: 16/23237-4
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2017
• End date: December 31, 2019
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Milton Santamaria Júnior
• Grantee: Milton Santamaria Júnior
• Host Institution: Pró-Reitoria de Pós-Graduação e Pesquisa. Centro Universitário Hermínio Ometto (UNIARARAS). Araras , SP, Brazil
• Associated researchers: Gláucia Maria Tech dos Santos ; Guilherme Ferreira Caetano ; Marcelo Augusto Marretto Esquisatto ; Thiago Antônio Moretti de Andrade
• Associated scholarship(s): 17/13361-2 - Characterization of osteogenic profile in bone defects with grafting submitted to therapy with low intensity electric current and magnetic electrostimulation, BP.TT

Abstract

The bone has a high capacity for repair and regeneration. Large bone defects represent a significant health problem and one of the greatest clinical challenges in reconstructive bone surgery that utilize a number of procedures, which most often are expensive and do not meet expectations of the patient. One of the purposes of the research involving bone repair is to reduce the failure, and different therapeutic resources have been used in clinical practice to improve the quality of bone consolidation. The development of new materials osteoinductive and osteoconductive biocompatible and the search by the more effective endogenous stimulation in bone repair are the strategies most used in the studies. Biomaterials used as bone substitutes and combined with other techniques bio-inducers can provide promising results in the bone repair process. Bovine bone presents similar properties to human bone tissue and has been widely used in procedures that use bone grafting. Different processing routes alter their characteristics in the interaction with living bone tissue and osseointegration. Bioactive glasses are excellent biocompatible osteoconductors, with angiogenic properties and are presented as another material of choice due to their greater availability. The bone also responds favorably to the application of electrical currents, because it acts on pathways that involve proliferation and differentiation of the osteogenic cells besides being an antimicrobial agent. In turn the magnetic electrostimulation has shown beneficial effects on osteogenesis. In this study we pretend to compare the effects of the application of low-intensity electric current and magnetic electrostimulation in the repair of bone defects that require grafting since they are non-invasive techniques and can be used in ambulatory procedures. The research in bone defects is promising since these, when induced in animal models, have shown excellent results with good prospects for future clinical application in humans. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CALSA, BRUNO; BORTOLANCA, TAINA JAQUELINE; MASIERO, BEATRIZ CALLONI; MARRETTO ESQUISATTO, MARCELO AUGUSTO; DE OLIVEIRA, CAMILA ANDREA; CATISTI, ROSANA; SANTAMARIA-JR, MILTON. Maxillary and dental development in the offspring of protein-restricted female rats. European Journal of Oral Sciences, v. 130, n. 6, p. 13-pg., 2022-10-05. (16/23237-4)

BAGNE, LEONARDO; OLIVEIRA, MARAIARA A.; PEREIRA, AMANDA T.; CAETANO, GUILHERME F.; OLIVEIRA, CAMILA A.; ARO, ANDREA A.; CHIAROTTO, GABRIELA B.; SANTOS, GLAUCIA M. T.; MENDONCA, FERNANDA A. S.; SANTAMARIA-JR, MILTON. Electrical therapies act on the Ca2+/CaM signaling pathway to enhance bone regeneration with bioactive glass [S53P4] and allogeneic grafts. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 109, n. 12, p. 2104-2116, DEC 2021. (16/23237-4, 17/13361-2)

HELAEHIL, JULIA VENTURINI; HUANG, BOYANG; BARTOLO, PAULO; SANTAMARIA-JR, MILTON; CAETANO, GUILHERME FERREIRA. Bone regeneration: The influence of composite HA/TCP scaffolds and electrical stimulation on TGF/BMP and RANK/RANKL/OPG pathways. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, v. 56, n. 2, p. 7-pg., 2025-01-17. (18/21167-4, 16/23237-4)

HELAEHIL, JULIA VENTURINI; HELAEHIL, LUIZA VENTURINI; ALVES, LARYSSA FERNANDA; HUANG, BOYANG; SANTAMARIA, MILTON; BARTOLO, PAULO; CAETANO, GUILHERME FERREIRA. Electrical Stimulation Therapy and HA/TCP Composite Scaffolds Modulate the Wnt Pathways in Bone Regeneration of Critical-Sized Defects. BIOENGINEERING-BASEL, v. 10, n. 1, p. 15-pg., 2023-01-01. (18/21167-4, 16/23237-4)