A systems approach to identify and validate novel therapeutic targets to improve cardiac repair and regeneration following myocardial infarction

• Grant number: 16/50439-7
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2017
• End date: October 31, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: University of Virginia
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: José Eduardo Krieger
• Grantee: José Eduardo Krieger
• Principal researcher abroad: Jeff Sauceman
• Institution abroad: University of Virginia (UVa), United States
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 13/17368-0 - Cardiovascular genomics: mechanisms & novel therapeutics - CVGen mech2ther, AP.TEM

Abstract

The objective of this exchange proposal is to stimulate collaboration between a biomedical engineer Dr. Saucerman and a physiologist Dr. Krieger, both of which are developing therapies based on cardiac regeneration. Dr. Saucerman is well prepared to identify novel therapeutic targets using computational analysis of Dr. Krieger cardiac regeneration experiments. Likewise, Dr. Krieger is well prepared to validate targets predicted by Dr. Saucerman computational analyses using in vivo animal models of cardiac regeneration. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIBEIRO-SILVA, JOAO CARLOS; NOLASCO, PATRICIA; KRIEGER, JOSE EDUARDO; MIYAKAWA, AYUMI AUREA. Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 18, SEP 2021. (16/50439-7, 15/11139-5, 14/50889-7)

JENSEN, LEONARDO; NERI, ELIDA; BASSANEZE, VINICIUS; DE ALMEIDA OLIVEIRA, NATHALIA C.; DARIOLLI, RAFAEL; TURACA, LAURO T.; LEVY, DEBORA; VERONEZ, DOUGLAS; FERRAZ, MARIANA S. A.; ALENCAR, ADRIANO M.; et al. Integrated molecular, biochemical, and physiological assessment unravels key extraction method mediated influences on rat neonatal cardiomyocytes. Journal of Cellular Physiology, v. 233, n. 7, p. 5420-5430, JUL 2018. (16/50439-7, 13/17368-0, 11/19678-1, 15/50216-5)