Mucoadhesive delivery systems for the release of drugs on intestinal mucosa

• Grant number: 17/16324-0
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2017
• End date: October 31, 2019
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Maria Palmira Daflon Gremião
• Grantee: Maria Palmira Daflon Gremião
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated researchers: Beatriz Stringhetti Ferreira Cury

Abstract

Nanostructured systems with mucoadhesive properties have great potential to be employed in drug release. These systems may increase the residence time of the systems at the site of action or absorption, enhancing drug contact with the mucosal epithelial barrier. The increased of the residence time and of the accumulation of drugs at pathological sites associated with drug controlled release can be enhance the effective concentration of drug at the site of action or absorption and increase therapeutic efficacy, as well as minimize the side-effects. The nanostructured systems have a high surface area and possibility of modulation of surface charge that can modify the properties of distribution and transport of drugs through the biological membranes. These systems have potential to a wide variety of applications especially within of protection against chemical and / or enzymatic degradation and gastrointestinal environment. The main aim this project is to analyze the effects of nanoparticles based in chitosan (QS), hydroxypropylmethylcellulose phthalate (HPMC) and hyaluronic acid (HA) in the interaction with mucus and in the intestinal mucosa permeation of methotrexate and zidovudine (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, NATALIA N.; GRANJA, SARA; BONI, FERNANDA ISADORA; FERREIRA, LEONARDO M. B.; REIS, RUI M.; BALTAZAR, FATIMA; GREMIAO, MARIA PALMIRA D.. A novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinnamic acid with cetuximab using nanotechnology-based delivery systems. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 3, SI, JAN 2020. (18/04546-1, 17/16324-0, 16/09671-3)

FERREIRA, LEONARDO M. B.; DOS SANTOS, ALINE M.; BONI, FERNANDA ISADORA; DOS SANTOS, KAREN C.; ROBUSTI, LEDA M. GORLA; DE SOUZA, MAURICIO P. C.; FERREIRA, NATALIA N.; CARVALHO, SUZANA G.; CARDOSO, VALERA M. O.; CHORILLI, MARLUS; et al. Design of chitosan-based particle systems: A review of the physicochemical foundations for tailored properties. Carbohydrate Polymers, v. 250, DEC 15 2020. (17/16324-0, 14/50928-2)

FERREIRA, LEONARDO M. B.; ALONSO, JOVAN D.; KIILL, CHARLENE P.; FERREIRA, NATALIA N.; BUZZA, HILDE H.; MARTINS DE GODOI, DENIS R.; DE BRITTO, DOUGLAS; ASSIS, ODILIO BENEDITO G.; SERAPHIM, THIAGO V.; BORGES, JULIO CESAR; et al. Exploiting supramolecular interactions to produce bevacizumab-loaded nanoparticles for potential mucosal delivery. EUROPEAN POLYMER JOURNAL, v. 103, p. 238-250, JUN 2018. (12/13446-4, 16/09671-3, 17/16324-0, 12/10174-3)

FERREIRA, NATALIA N.; GRANJA, SARA; BONI, FERNANDA ISADORA; FERREIRA, LEONARDO M. B.; REIS, RUI M.; BALTAZAR, FATIMA; GREMIAO, MARIA PALMIRA D.. A novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinnamic acid with cetuximab using nanotechnology-based delivery systems. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 3, p. 16-pg., 2020-01-24. (18/04546-1, 17/16324-0, 16/09671-3)

DE OLIVEIRA CARDOSO, VALERIA MARIA; DAFLON GREMIAO, MARIA PALMIRA; FERREIRA CURY, BEATRIZ STRINGHETTI. Mucin-polysaccharide interactions: A rheological approach to evaluate the effect of pH on the mucoadhesive properties. International Journal of Biological Macromolecules, v. 149, p. 234-245, APR 15 2020. (17/16324-0, 14/50928-2, 15/21412-0)

CESAR, MARIANA BIONDI; POLI, HAMISH; PIAZZA, RODOLFO DEBONE; COSTA MARQUES, RODRIGO FERNANDO; HERCULANO, RONDINELLI DONIZETTI; GRONDAHL, LISBETH. Dispersion of hydroxyapatite nanoparticles in natural rubber latex and poly lactic acid based matrices. Journal of Applied Polymer Science, v. 139, n. 20, p. 15-pg., 2022-01-28. (17/19603-8, 16/09736-8, 17/16324-0)

CARDOSO, VALERIA MARIA DE OLIVEIRA; KIRALY, VANESSA THOMAZ RODRIGUES; BONI, FERNANDA ISADORA; FERREIRA, NATALIA NORONHA; FERREIRA, LEONARDO M. B.; PEREIRA, FABIOLA MANHAS VERBI; BORGES, JULIO CESAR; CURY, BEATRIZ STRINGHETTI FERREIRA; GREMIAO, MARIA PALMIRA DAFLON. Rational design of nanocarriers based on gellan gum/retrograded starch exploiting polyelectrolyte complexation and ionic cross-linking processes: A potential technological platform for oral delivery of bevacizumab. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 66, DEC 2021. (17/16324-0, 14/50928-2, 15/21412-0)