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Mechanisms involved in the biphasic thermoregulatory response to systemic inflammation in chicks: an integrated approach from the system to the mitochondria


During severe sepsis and associated systemic inflammatory responses, there may be a drop in body temperature (Tc) rather than fever. Formerly considered as an unregulated response of the organism, this fall of Tc has been interpreted today in mammals as a regulated, transitory and beneficial event. Although it has already been described in birds, there is no evidence that this thermal response is regulated or not nor the specific mechanisms involved in the biphasic response (Tc drop followed by fever) in the face of systemic inflammation in known. Thus, the hypothesis of the present study is that the reduction of Tc induced by systemic inflammation in birds is a regulated response, mediated by specific pro-inflammatory agents, which means a reduction of energy expenditure for the animal. To test this hypothesis, we will treat 5-day old broiler chicks with a high dose of LPS (100 microg/kg, Gram negative bacteria endotoxin) and analyse: i) the autonomic (metabolic rate, pulmonary ventilation, cutaneous heat loss index) and behavioral (huddling) thermoregulatory responses, b) the muscular and hepatic mitochondrial respiration, c) the thermoeffector responses to reduced energy availabilit, and d) the involvement of the cyclooxygenases 1 and 2 as well as the prostaglandins E2 and D2 during Tc drop and subsequent fever induced by LPS. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CRISTINA-SILVA, CAROLINE; GARGAGLIONI, LUCIANE H.; BICEGO, KENIA CARDOSO. A thermoregulatory role for the medullary raphe in birds. Journal of Experimental Biology, v. 224, n. 9, . (17/17278-2, 19/14646-6, 17/12627-9)
CRISTINA-SILVA, CAROLINE; AMARAL-SILVA, LARA; SANTOS, KASSIA MOREIRA; CORREA, GABRIELA MONTEIRO; DA SILVA, WELEX CANDIDO; FERNANDES, MARCIA H. M. R.; DA SILVA, GLAUBER S. F.; GARGAGLIONI, LUCIANE H.; ALMEIDA, MARIA C.; BICEGO, KENIA C.. Cutaneous TRPV4 Channels Activate Warmth-Defense Responses in Young and Adult Birds. FRONTIERS IN PHYSIOLOGY, v. 13, p. 13-pg., . (17/17278-2, 17/12627-9, 17/00864-6, 18/01796-7, 15/04849-6, 19/06211-0, 15/02991-0)
DO AMARAL-SILVA, LARA; DA SILVA, WELEX CANDIDO; GARGAGLIONI, LUCIANE HELENA; BICEGO, KENIA CARDOSO. Metabolic trade-offs favor regulated hypothermia and inhibit fever in immune-challenged chicks. Journal of Experimental Biology, v. 225, n. 4, p. 15-pg., . (17/00864-6, 17/12627-9)

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