| Grant number: | 17/21581-2 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | April 02, 2018 |
| End date: | April 01, 2019 |
| Field of knowledge: | Agronomical Sciences - Animal Husbandry |
| Principal Investigator: | Kênia Cardoso Bícego |
| Grantee: | Lara do Amaral Silva |
| Supervisor: | Warren William Burggren |
| Host Institution: | Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil |
| Institution abroad: | University of North Texas, United States |
| Associated to the scholarship: | 17/00864-6 - Physiological and biochemical mechanisms of thermal response to systemic inflammation in chicks, BP.DR |
Abstract Birds are frequently exposed to pollutants in the form of polycyclic aromatic hydrocarbons (PAHs), including dioxins, which may be unintentionally produced by chemical reactions and combustion and cannot often be controlled. Birds exposed to dioxin, mainly during developmental phase, show many physiological changes including affecting mechanisms involved in energy metabolism and immunity. Those effects may influence the inflammatory and thermoregulatory responses to pathogens, which would be similar to what happens in mammals. Although the great importance of inflammatory and thermoregulatory responses in birds is well known, there is no data about the effects of dioxin exposure on these processes in those animals. Thus the aim of the present study is to use a molecular-to-systemic approach to investigate the effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a chlorinated PAH, during the embryonic development on inflammatory and thermoregulatory responses to LPS (exdotoxin of gram negative bacteria) in post-hatching chicks. To this end, intact eggs or injected with TCDD (10 and 20 ng/egg) or vehicle will be incubated; 5-7 days after hatching, chicks will be injected with LPS (100 ug kg-1) or saline while body temperature and oxygen consumption will be measured. Then, chicks will be euthanized for blood analysis (blood gases, pH, hematocrit, Hb concentration) and transcriptome analysis of heart, brain, skeletal muscle, liver and kidney. | |
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