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Physiological and biochemical mechanisms of thermal response to systemic inflammation in chicks

Grant number: 17/00864-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2017
Effective date (End): September 30, 2020
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Production
Principal Investigator:Kênia Cardoso Bícego
Grantee:Lara do Amaral Silva
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):17/21581-2 - Inflammation in dioxin exposed birds (Gallus gallus): molecular to systemic responses, BE.EP.DR


During severe sepsis and associated systemic inflammatory responses, a drop in body temperature (Tc) instead fever can occur. Previously considered an uncontrolled response, nowadays it has been interpreted as a regulated, transitory and beneficial event in mammals. Although it has been described in birds, there is no evidence that this thermal response is regulated or not and no data of what are the specific mechanisms involved in the biphasic response (initial drop in Tc followed by fever) of systemic inflammation. Thus, the hypothesis of the present study is that the drop in Tc during systemic inflammation in birds is a regulated response, mediated by specific pro-inflammatory agents and represents a reduction of energy expenditure for the animal. To test this hypothesis, we will use a model of high dose of LPS (Gram negative bacteria endotoxin; 100 ¼g kg-1) peripherally injected in 5-day-old broiler chicks and analyze during biphasic response: i) autonomic (metabolic rate, pulmonary ventilation, cutaneous heat loss index) and behavioral (huddling) thermo-effector responses; ii) muscular and hepatic mitochondrial activities; iii) thermo-effector responses in a condition of reduced energy availability; iv) and the role of cyclooxygenases 1 and 2 as well as prostaglandins E2 and D2. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DO AMARAL-SILVA, LARA; GARGAGLIONI, LUCIANE H.; STEINER, ALEXANDRE A.; OLIVEIRA, MARCOS T.; BICEGO, KENIA CARDOSO. Regulated hypothermia in response to endotoxin in birds. JOURNAL OF PHYSIOLOGY-LONDON, v. 599, n. 11, p. 2969-2986, . (17/00864-6)
DO AMARAL-SILVA, LARA; DA SILVA, WELEX CANDIDO; GARGAGLIONI, LUCIANE HELENA; BICEGO, KENIA CARDOSO. Metabolic trade-offs favor regulated hypothermia and inhibit fever in immune-challenged chicks. Journal of Experimental Biology, v. 225, n. 4, p. 15-pg., . (17/00864-6, 17/12627-9)
CRISTINA-SILVA, CAROLINE; AMARAL-SILVA, LARA; SANTOS, KASSIA MOREIRA; CORREA, GABRIELA MONTEIRO; DA SILVA, WELEX CANDIDO; FERNANDES, MARCIA H. M. R.; DA SILVA, GLAUBER S. F.; GARGAGLIONI, LUCIANE H.; ALMEIDA, MARIA C.; BICEGO, KENIA C.. Cutaneous TRPV4 Channels Activate Warmth-Defense Responses in Young and Adult Birds. FRONTIERS IN PHYSIOLOGY, v. 13, p. 13-pg., . (17/17278-2, 17/12627-9, 17/00864-6, 18/01796-7, 15/04849-6, 19/06211-0, 15/02991-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Lara do Amaral. Anapyrexia and fever in response to endotoxin in birds: Metabolic trade-offs and biochemical mediators. 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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