Hyperprolactinemia and allergic inflammatory response of the lungs

• Grant number: 16/22364-2
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2017
• End date: October 31, 2018
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Luciano Freitas Felicio
• Grantee: Luciano Freitas Felicio
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Multiple factors determine the variation in patterns of allergic response of the lungs. Among the endogenous factors, the hormones have unique adaptive value because they influence functions in various systems. Prolactin is a peptide hormone that is secreted by the anterior pituitary gland and is known to regulate stress, reproduction, and a wide variety of physiological processes. The effects of prolactin on the immune system are complex. The hypothesis that pharmacologically induced short-term (5 days) and long-term (30 days) hyperprolactinemia can change the expression of allergic lung inflammatory response will be tested in sensitized rats challenged with ovalbumin (OVA) and in lactating rats. Lung cell influx, vascular permeability on cell migration profile in the lung, blood, and bone marrow will be evaluated. The expression of adhesion molecules, the production of cytokines, interleukins and mast cell degranulation will be measured. Also, histopathological evaluation of the lungs mucus production, the presence of collagen fibers and airway reactivity will be investigated in order to observe the pathological changes, in this experimental asthma model. The proposed study has the potential to generate meaningful data with both biological and clinical implications. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OCHOA-AMAYA, JULIETA E.; QUEIROZ-HAZARBASSANOV, NICOLLE; NAMAZU, LILIAN B.; CALEFI, ATILIO S.; TOBARUELA, CARLA N.; MARGATHO, RAFAEL; PALERMO-NETO, JOAO; LIGEIRO DE OLIVEIRA, ANA P.; FELICIO, LUCIANO F.. Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs. NEUROIMMUNOMODULATION, v. 25, n. 1, p. 34-41, 2018. (09/51886-3, 16/22364-2)

BARRETO, TALITA ROSSETTO; COSTOLA-DE-SOUZA, CAROLINA; MARGATHO, RAFAEL OLIVEIRA; QUEIROZ-HAZARBASSANOV, NICOLLE; RODRIGUES, SANDRA CAMPOS; FELICIO, LUCIANO FREITAS; PALERMO-NETO, JOAO; ZAGER, ADRIANO. Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice. International Immunopharmacology, v. 56, p. 43-50, MAR 2018. (15/02441-0, 16/22364-2, 13/18921-5, 09/51886-3)