Obesogenic programming: the role of maternal millieu and feto-placental interface

• Grant number: 17/11608-0
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2017
• End date: August 31, 2020
• Field of knowledge: Health Sciences - Nutrition - Malnutrition and Physiological Development
• Principal Investigator: Letícia Ignácio de Souza Zimmermann
• Grantee: Letícia Ignácio de Souza Zimmermann
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated researchers: Marciane Milanski Ferreira

Abstract

In last decades, humanity seems a pronounced increase in the prevalence of chronic noncommunicable diseases and increased public health expenditures for its treatment. Among these diseases, obesity is one of the most serious because its cellular and molecular mechanisms of adaptation can trigger the appearance of other types of metabolic diseases like diabetes, arterial hypertension and some kinds of cancer. Today, what we know is that a subclinical inflammatory environment that comes with this disease triggers a sequence of cyclical molecular events culminating with the loss of energy homeostasis control, a milieu that current medical-nutritional therapies do not reach the effectiveness to revert the process. Thus, the way that the external environment influences in responses of the organism and how this organism becomes more or less permissive to these insults take us to processes of transmission and self-perpetuation of disease, the metabolic programming. Establishing the placenta as a potential target in the link between the external / maternal environment in the progression of obesity in number of individuals can provision a significantly upgrade in scientific knowledge about tools for more effective therapeutic targets not only in the treatment but also to prevention of this epidemic disease. Also, this focus brings with it discussions about how the nutritional transition changed the current nutritional profile of the population, since we will come to understand how situations of disturbances in nutritional milieu (deprivation/excess of nutrients) can predispose individuals to a dangerous physiological panorama that is permissive to the excessive and harmful stock of body energy how fat. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VARELA SANCHES, ANA PAULA; DE OLIVEIRA, JOSILENE LOPES; FERREIRA, MAIRA SCHUCHTER; LIMA, BRUNA DE SOUZA; MIYAMOTO, JOSIANE ERICA; DE PAULA SIMINO, LAIS ANGELICA; TORSONI, MARCIO ALBERTO; TORSONI, ADRIANA SOUZA; MILANSKI, MARCIANE; IGNACIO-SOUZA, LETICIA. Obesity phenotype induced by high-fat diet leads to maternal-fetal constraint, placental inefficiency, and fetal growth restriction in mice. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 104, p. 17-pg., 2022-06-01. (17/11608-0)