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Obesogenic programming: the role of maternal millieu and feto-placental interface

Grant number: 17/11608-0
Support type:Regular Research Grants
Duration: December 01, 2017 - May 31, 2020
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Letícia Martins Ignácio de Souza
Grantee:Letícia Martins Ignácio de Souza
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Assoc. researchers:Marciane Milanski Ferreira

Abstract

In last decades, humanity seems a pronounced increase in the prevalence of chronic noncommunicable diseases and increased public health expenditures for its treatment. Among these diseases, obesity is one of the most serious because its cellular and molecular mechanisms of adaptation can trigger the appearance of other types of metabolic diseases like diabetes, arterial hypertension and some kinds of cancer. Today, what we know is that a subclinical inflammatory environment that comes with this disease triggers a sequence of cyclical molecular events culminating with the loss of energy homeostasis control, a milieu that current medical-nutritional therapies do not reach the effectiveness to revert the process. Thus, the way that the external environment influences in responses of the organism and how this organism becomes more or less permissive to these insults take us to processes of transmission and self-perpetuation of disease, the metabolic programming. Establishing the placenta as a potential target in the link between the external / maternal environment in the progression of obesity in number of individuals can provision a significantly upgrade in scientific knowledge about tools for more effective therapeutic targets not only in to treatment but also to prevention of this epidemic disease. Also, this focus brings with it discussions about how the nutritional transition changed the current nutritional profile of the population, since we will come to understand how situations of disturbances in nutritional milieu (deprivation/excess of nutrients) can predispose individuals to a dangerous physiological panorama that is permissive to the excessive and harmful stock of body energy how fat. (AU)