Sustentable use of the Brazilian biodiversity: Evaluation of chemical-pharmacological of the hight plants:Indigofera hirsuta (Fabaceae)

• Grant number: 08/01682-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2009
• End date: December 31, 2009
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Lourdes Campaner dos Santos
• Grantee: Adriana Candido da Silva Moura
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 02/05503-6 - Sustainable use of the Brazilian biodiversity: chemical and pharmacological prospection on higher plants, AP.BTA.TEM

Abstract

The apparent incompatibility between chemical and pharmacological investigation of a plant species can be solved with the strong determination of dealing rationally with the problem. The research groups on Natural Products Chemistry from the IQ-Araraquara-Unesp, on Pharmacology, from IB-Unicamp and IB-Botucatu-Unesp and on Biological Sciences, from FCF-Araraquara-Unesp have started a collaboration 4 years ago, and have already produced a significative amount of work, with relevant results on the investigation of plant species with anti-ulcer, anti-oxidant, analgesic, anti-inflammatory and antimicrobial, anti tuberculosis, immunology, cytotocity and mutagenic activities. The cytotocity and mutagenic activities are correlationation with anti-tumoral activity. These results arose from an approach that includes ethnobotanical and ethnopharmacological research, assays with crude extracts or infusions, chemical screening to determine the new chemical classes of compounds, isolation and structural determination of the compounds and use the compounds or enriched fractions to determine the possible pharmacological mechanisms of the action involved with the detected properties. This project deals with the continuation of the integrated chemical and pharmacological investigation of plant extracts, this time investigating species that composes the bioma Cerrado and Mata Atlantica of the State São Paulo, investigation ago the specie Indigofera hirsuta.To perform the phytochemical step we intend to use the usual chromatographic techniques, mainly those for the analysis of polar substances (GPC, XAD2, DCCC, HSCC, HPLC, etc), and to determine the structure of the isolated compounds through spectrometric methods (NMR, IR, UV, MS). To evaluate the anti-ulcer activities, groups the IB-Unicamp and IB-Botucatu-Unesp and on Biological Sciences, from FCF-Araraquara-Unesp.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MOURA, Adriana Candido da Silva. Uso sustentável da biodiversidade brasileira: avaliação químico-farmacológica de plantas superiores: Indigofera hirsuta (Fabaceae). 2010. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.