Studies Towards the Synthesis of the Potent Tripanocidal (±)-Komaroviquinona

• Grant number: 09/03726-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2009
• End date: August 31, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Antonio Carlos Bender Burtoloso
• Grantee: Rafael Fonseca Pereira
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

Komaroviquinone, a diterpene that was recently isolated from the plant Dracocephalum komarovi, is a potent candidate in studies towards the treatment of Chagas disease, an important disease for Brazil. Komaroviquinone showed itself more active against T. cruzi (IC50= 9 nano molar) when compared to currently used drugs to treat Chagas disease and its mechanism of action is closely related to the T. cruzi old yellow enzyme (TcOYE), found in the parasite. This project deals with the synthesis of racemic komaroviquinone, employing an epoxide ring opening reaction and an intramolecular Friedel-Crafts acylation as the key steps in the route to be studied.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PEREIRA, Rafael Fonseca. Studies toward the synthesis of trypanocidal (±)-komaroviquinone. 2011. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC/BT) São Carlos.