The proposal aims the total synthesis of the diterpenes (-)-Brussonol and (+)-Komaroviquinone, as well as possible analogs and their racemic forms. The main steps of this proposal constitute the epoxide-opening as well as a intramolecular Friedel-Crafts reaction. It is noteworthy that these steps were never previously employed for the construction of this type of skeleton and may be applied to other substances of similar structure. Furthermore, this study can promote the development of a new methodology for the opening of congested epoxides from oxygenated aromatic rings. Synthesizing these compounds and their analogs, the evaluation of their trypanocidal activity will be carried out.
News published in Agência FAPESP Newsletter about the scholarship: