Effect of dietary magnesium deficiency in the insulin resistance and in the inflammatory response in rats fed with high-fat diet

• Grant number: 09/05624-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2009
• End date: March 31, 2013
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Célia Colli
• Grantee: Cristiane Hermes Sales
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The obesity epidemic affects several extracts of the world population, and because of adverse events linked to this disease, resulting from increased body weight, percentage of body fat, associated to food errors, predisposes to increased risk of developing chronic diseases such as type 2 diabetes, cardiovascular disease, hypertension, dyslipidemia, and other diseases, which incidence accompanies the ascent of obesity and increased risk of morbidity and mortality. Together to the genesis of factors associated with obesity, it speculated that the magnesium (Mg) deficiency, increasingly demonstrated in population studies, can be a key factor to increase the potential risks of disorders resulting from obesity, which, as obesity, commonly, are accompanied by a marked inflammatory response. In this study is aimed to evaluate the effects of exposure to different concentrations of dietary Mg on insulin resistance and inflammatory response in rats fed high-fat diet. First, will be a pilot study to test the high-fat diet. After, other rats will be exposed to the different concentrations of dietary Mg associated a high-fat diet, and evaluated parameters of inflammatory response and insulin resistance, and the assessment of the Mg status through different compartments.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALES, CRISTIANE HERMES; DOS SANTOS, ADRIANA RODRIGUES; CORREA CINTRA, DENNYS ESPER; COLLI, CELIA. Magnesium-deficient high-fat diet: Effects on adiposity, lipid profile and insulin sensitivity in growing rats. Clinical Nutrition, v. 33, n. 5, p. 879-888, OCT 2014. (09/05624-7)

DE CARLI, EDUARDO; LOBO, ALEXANDRE R.; SALES, CRISTIANE H.; TEIXEIRA, PRYSCILA D. S.; SALES, ANA LINA DE CARVALHO C.; COLLI, CELIA. Short-term dietary magnesium restriction lowers spleen iron concentrations in growing rats fed a high-fat diet. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 59, n. 2, 2, SI, p. 1298-1303, DEC 2014. (09/05624-7, 11/08895-1, 10/05644-5)

DE CARLI, EDUARDO; LOBO, ALEXANDRE R.; SALES, CRISTIANE H.; TEIXEIRA, PRYSCILA D. S.; SALES, ANA LINA DE CARVALHO C.; COLLI, CELIA. Short-term dietary magnesium restriction lowers spleen iron concentrations in growing rats fed a high-fat diet. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 59, n. 2, p. 6-pg., 2014-12-01. (11/08895-1, 09/05624-7, 10/05644-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SALES, Cristiane Hermes. Effect of dietary magnesium deficiency on insulin resistance and on inflammatory and oxidative status in rats fed with high-fat diet. 2013. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.