Study and development of nanocomposites containing Metallic/Magnetic Nanoparticles-Biomolecules conjugated: synthesis and application in nanomedicine

• Grant number: 09/11679-9
• Support type: Scholarships in Brazil - Master
• Effective date (Start): March 01, 2010
• Effective date (End): February 29, 2012
• Field of knowledge: Physical Sciences and Mathematics - Physics
• Principal Investigator: Valtencir Zucolotto
• Grantee: Valéria Spolon Marangoni
• Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

Organic / inorganic hybrid composites have been widely investigated due to their potential applications in nanobiotechnology. The synthesis of metallic and magnetic nanoparticles conjugated with bioactive molecules present high potential for biomedical applications. In this project, metallic and magnetic nanoparticles will be synthesized and complexed with specific proteins. Proteins of the lectin family will be initially employed, and the studies will focus on the optimization of the NPs/protein bionanocomposites synthesis and their characterization via spectroscopic, microscopy and electrochemistry techniques. It will also be studied the interaction of nanobiocomposites with cell membrane model. Advanced spectroscopic and morphological techniques will be used not only to investigate the structure and the stabilization mechanisms, but also to investigate the biophysicochemical interactions at the nano-bio interface.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MARANGONI, Valéria Spolon. Estudo e desenvolvimento de nanocompósitos contendo nanopartículas de ouro conjugadas com biomoléculas: síntese e aplicações em nanomedicina. 2012. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Física de São Carlos São Carlos.