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Purification and characterization of compounds isolated from plants with larvicidal activity.

Grant number: 09/17058-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2010
Effective date (End): April 30, 2014
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Maria Luiza Vilela Oliva
Grantee:Natalia Neto dos Santos Nunes
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Aedes aegypti transmits etiologic agents of yellow fever and dengue. Vaccine for dengue virus is not available and vector control is essential to minimize dengue incidence. Aqueous extracts 1% (p/v) of the seed tegument and cotyledon of Carica did not show larvicidal activity when tested separately. However, the mixture of both caused 100% of larval mortality at concentration of approximately 5mg/mL, in bioassay. This project aims the characterization and the establishment of the mechanism of action of the toxic activity found in Carica seeds on the larvae of A. aegypti.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NUNES, NATALIA N. S.; FERREIRA, RODRIGO S.; SILVA-LUCCA, ROSEMEIRE A.; DE SA, LEONARDO F. R.; DE OLIVEIRA, ANTONIA ELENIR A.; CORREIA, MARIA TEREZA DOS S.; PAIVA, PATRICIA MARIA G.; WLODAWER, ALEXANDER; OLIVA, MARIA LUIZA V. Potential of the Lectin/Inhibitor Isolated from Crataeva tapia Bark (CrataBL) for Controlling Callosobruchus maculatus Larva Development. Journal of Agricultural and Food Chemistry, v. 63, n. 48, p. 10431-10436, DEC 9 2015. Web of Science Citations: 6.
NUNES, NATALIA N. DOS S.; SANTANA, LUCIMEIRE A.; SAMPAIO, MISAKO U.; LEMOS, FRANCISCO J. A.; OLIVA, MARIA LUIZA. The component of Carica papaya seed toxic to A-aegypti and the identification of tegupain, the enzyme that generates it. Chemosphere, v. 92, n. 4, p. 413-420, JUL 2013. Web of Science Citations: 8.

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