|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||May 01, 2010|
|Effective date (End):||April 30, 2014|
|Field of knowledge:||Biological Sciences - Biochemistry - Chemistry of Macromolecules|
|Principal Investigator:||Maria Luiza Vilela Oliva|
|Grantee:||Natalia Neto dos Santos Nunes|
|Home Institution:||Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil|
Aedes aegypti transmits etiologic agents of yellow fever and dengue. Vaccine for dengue virus is not available and vector control is essential to minimize dengue incidence. Aqueous extracts 1% (p/v) of the seed tegument and cotyledon of Carica did not show larvicidal activity when tested separately. However, the mixture of both caused 100% of larval mortality at concentration of approximately 5mg/mL, in bioassay. This project aims the characterization and the establishment of the mechanism of action of the toxic activity found in Carica seeds on the larvae of A. aegypti.