Bacillus thuringiensis insecticidal proteins are widely used as biopesticides. However, the resistance evolution on insect pests is the biggest obstacle to the successful application of these insecticides on biological control programs. To avoid this process is necessary to understand how the mode of action of these toxins is. Studies evolving different toxin proteins of B. thuringiensis and their interactions with membrane receptors of the intestinal epithelium at target insects are very important to evaluate strategies that may prevent or control the resistance evolution of these pests to toxins. Therefore, the aim of this research is to verify the toxicity of Cry and VIP proteins of B. thuringiensis (crystal and vegetative insecticidal proteins) on two populations of Diatraea saccharalis, prioring the toxicity and biochemical analysis of the mode of action of these toxins, in order to prevent the resistance evolution on insect pests.
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