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Influence of glycosaminoglycans in the inflammatory process and cellular therapy using endothelial progenitor cells for recovery of mice arterial lesion.

Grant number: 10/01119-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2010
Effective date (End): August 31, 2014
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Cristina Pontes Vicente
Grantee:Juliana Aparecida Preto de Godoy
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The endothelial progenitor cells (EPC) were first described by Asahara in 1997. These cells were able to migrate to the site of endothelial lesion and differentiate into mature endothelial cells promoting new vessel formation and helping in endothelium recovery. Thrombosis, oxidative stress and inflammatory process can be initiated by an arterial lesion and affect proliferation of local endothelial and smooth muscle cells, also influencing EPC migration to the site of injury. Dermatan sulfate (DS) and fucosylated chondroitin sulfate (FuCS) are glycosaminoglycan (GAGs) with well known antithrombotic and anticoagulant activities, their anti-inflammatory function was recently described. This project proposes to analyze DS and FuCS activity in the inflammatory process and EPC, used as cellular therapy, migration, proliferation and differentiation, after an arterial lesion. To analyze GAGs influence in inflammation, EPC migration and neointima development we will study the expression of P-selectin, ICAM-1, SDF-1, VEGF, eNOS, NF-k² and TGF-². The expression of these proteins is directly correlated with cell migration proliferation and inflammatory reaction. The determination of these factors can help understanding the mechanisms involved in endothelium recovery after lesions and also developing new therapies for cardiovascular disease treatments, using the EPC together with anti-inflammatory and anticoagulant drugs.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GODOY, JULIANA A. P.; BLOCK, DANIEL B.; TOLLEFSEN, DOUGLAS M.; WERNECK, CLAUDIO C.; VICENTE, CRISTINA P.. Dermatan sulfate and bone marrow mononuclear cells used as a new therapeutic strategy after arterial injury in mice. CYTOTHERAPY, v. 13, n. 6, p. 695-704, . (10/11474-5, 10/01119-3, 09/00950-3)
GODOY, JULIANA A. P.; CARNEIRO, GIANE D.; SIELSKI, MICHELI S.; BARBOSA, GUILHERME O.; WERNECK, CLAUDIO C.; VICENTE, CRISTINA P.. Combined dermatan sulfate and endothelial progenitor cell treatment: action on the initial inflammatory response after arterial injury in C57BL/6 mice. CYTOTHERAPY, v. 17, n. 10, p. 1447-1464, . (10/01119-3, 12/23640-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GODOY, Juliana Aparecida Preto de. Influence of glycosaminoglycans and cellular therapy in the inflammation after arterial lesion in mice. 2014. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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