Arousal hemodynamic evaluation during sleep in patients with hypertension

• Grant number: 10/18183-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2011
• End date: March 31, 2012
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Linda Massako Ueno Pardi
• Grantee: Carlos Eduardo Verzine Garcia
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Sleeping arousal is defined by quick electroencephalogram activity elevation (3 to 15 seconds). Arousal is caused by sympathetic activation due to apnea events during sleep or periodic leg movements, as blood pressure elevation and smooth movements (like respiratory efforts or jaw myography changes), associated with sleep fragmentation that lead deleterious effects to cardiovascular system and individuals life quality. However, few are known about hemodynamic changes during spontaneous (cortical) arousal during sleep in hypertensive individuals without sleep apnea. The study's objective is to analyze arousal hemodynamic variables that occur during non-induced sleep in sedentary hypertensive and non-hypertensive individuals (14 normal volunteers and 14 stage 1 and 2 hypertensive volunteers). All individuals will realize night polissonography simultaneous to beat-to-beat CF (ECG), BP (Portapress) and respiratory frequency monitoring signs will be collected. All participants with apnea-hipopnea index>5, compatible with sleep apnea diagnosis will be excluded. All polissonography records will be analyzed particularly in NREM sleep stage 2. 4 arousals of each patient that last 8 to 10 seconds will be chosen. Totally, 30 seconds of each event will be analyzed (15 before and 15 seconds after the arousal's beginning). The arousal hemodynamic differences and characteristics of each group (hypertensive and non-hypertensive) and of beginning stage 2 and final stage 2 will be compared with T-test. Differences with P<0,05 will be considered significant. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GARCIA, CARLOS E. V.; DRAGER, LUCIANO F.; KRIEGER, EDUARDO M.; NEGRAO, CARLOS E.; BORTOLOTTO, LUIZ A.; LORENZI-FILHO, GERALDO; UENO, LINDA M.. Arousals Are Frequent and Associated With Exacerbated Blood Pressure Response in Patients With Primary Hypertension. AMERICAN JOURNAL OF HYPERTENSION, v. 26, n. 5, p. 617-623, MAY 2013. (10/18183-6)