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Use of low-level laser and light-emitting diode therapy to increase muscle performance: from in vitro and experimental studies to clinical applications

Grant number: 10/07194-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2011
Effective date (End): July 31, 2014
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Nivaldo Antonio Parizotto
Grantee:Cleber Ferraresi
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):12/05919-0 - Effects of low level laser therapy on modulation of the transcriptome, immunohistochemistry of muscle tissue and physical performance of young men undergoing physical strength training, BE.EP.DR


Recent studies have used low-level laser therapy and light-emitting diode therapy to increase muscle performance in experimental models as well as in randomized clinical trials. This current study has the perspective of detailing the effects of these therapies on muscle performance in vitro, experimental models and clinical trials to elucidate all of main mechanisms of action on skeletal muscle submitted to strength exercises or fatigue exercises. Among all possible mechanisms, we highlight the gene expression analysis (human genome) by microarrays. In addition, were proposed randomized clinical trials with young healthy males submitted to strength training or high intensity and/ or treated with low-level laser therapy/ LED therapy. Moreover, experimental models will assess the effects of pre or post laser/ LED therapy on muscles to decrease muscle fatigue. An in vitro study with muscle cell lineage will be performed to identify more mechanisms of action. The set of all these studies will allow a better understanding of these therapies to increase muscle performance that in the future can be widely used in clinical practice. (AU)

Matéria(s) publicada(s) na Revista Pesquisa FAPESP sobre a bolsa::
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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERRARESI, CLEBER; BALDISSERA, VILMAR; PEREZ, SERGIO E. A.; JUNIOR, EUCLIDES M.; BAGNATO, VANDERLEI S.; PARIZOTTO, NIVALDO A.. One-repetition maximum test and isokinetic leg extension and flexion: Correlations and predicted values. ISOKINETICS AND EXERCISE SCIENCE, v. 21, n. 1, p. 69-76, . (10/07194-7)
BELTRAME, THOMAS; FERRARESI, CLEBER; PARIZOTTO, NIVALDO ANTONIO; BAGNATO, VANDERLEI SALVADOR; HUGHSON, RICHARD L.. Light-emitting diode therapy (photobiomodulation) effects on oxygen uptake and cardiac output dynamics during moderate exercise transitions: a randomized, crossover, double-blind, and placebo-controlled study. Lasers in Medical Science, v. 33, n. 5, p. 1065-1071, . (10/07194-7)
FERRARESI, CLEBER; BERTUCCI, DANILO; SCHIAVINATO, JOSIANE; REIFF, RODRIGO; ARAUJO, AMELIA; PANEPUCCI, RODRIGO; MATHEUCCI, JR., EUCLIDES; CUNHA, ANDERSON FERREIRA; ARAKELIAN, VIVIAN MARIA; HAMBLIN, MICHAEL R.; et al. Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 95, n. 10, p. 746-757, . (12/05919-0, 10/07194-7)
FERRARESI, CLEBER; PARIZOTTO, NIVALDO ANTONIO; PIRES DE SOUSA, MARCELO VICTOR; KAIPPERT, BEATRIZ; HUANG, YING-YING; KOISO, TOMOHARU; BAGNATO, VANDERLEI SALVADOR; HAMBLIN, MICHAEL R.. Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. Journal of Biophotonics, v. 8, n. 9, p. 740-754, . (12/05919-0, 10/07194-7)
VATANSEVER, FATMA; DE MELO, WANESSA C. M. A.; AVCI, PINAR; VECCHIO, DANIELA; SADASIVAM, MAGESH; GUPTA, ASHEESH; CHANDRAN, RAKKIYAPPAN; KARIMI, MAHDI; PARIZOTTO, NIVALDO A.; YIN, RUI; et al. Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy, and beyond. FEMS MICROBIOLOGY REVIEWS, v. 37, n. 6, p. 955-989, . (11/06240-8, 12/05919-0, 10/07194-7)
DE BRITO VIEIRA, WOUBER HERICKSON; BEZERRA, RAPHAEL MACHADO; SALDANHA QUEIROZ, RENATA ALENCAR; BRAGA MACIEL, NICIA FARIAS; PARIZOTTO, NIVALDO ANTONIO; FERRARESI, CLEBER. Use of Low-Level Laser Therapy (808 nm) to Muscle Fatigue Resistance: A Randomized Double-Blind Crossover Trial. Photomedicine and Laser Surgery, v. 32, n. 12, p. 678-685, . (12/05919-0, 10/07194-7)
FERRARESI, CLEBER; KAIPPERT, BEATRIZ; AVCI, PINAR; HUANG, YING-YING; DE SOUSA, MARCELO V. P.; BAGNATO, VANDERLEI S.; PARIZOTTO, NIVALDO A.; HAMBLIN, MICHAEL R.. Low-level Laser (Light) Therapy Increases Mitochondrial Membrane Potential and ATP Synthesis in C2C12 Myotubes with a Peak Response at 3-6 h. Photochemistry and Photobiology, v. 91, n. 2, p. 411-416, . (12/05919-0, 10/07194-7)
FERRARESI, CLEBER; PIRES DE SOUSA, MARCELO VICTOR; HUANG, YING-YING; BAGNATO, VANDERLEI SALVADOR; PARIZOTTO, NIVALDO ANTONIO; HAMBLIN, MICHAEL R.. Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice. Lasers in Medical Science, v. 30, n. 4, p. 1259-1267, . (12/05919-0, 10/07194-7)
FERRARESI, CLEBER; DOS SANTOS, RICARDO VINICIUS; MARQUES, GUILHERME; ZANGRANDE, MARCELO; LEONALDO, ROBERLEY; HAMBLIN, MICHAEL R.; BAGNATO, VANDERLEI SALVADOR; PARIZOTTO, NIVALDO ANTONIO. Light-emitting diode therapy (LEDT) before matches prevents increase in creatine kinase with a light dose response in volleyball players. Lasers in Medical Science, v. 30, n. 4, p. 1281-1287, . (12/05919-0, 10/07194-7)
TATMATSU-ROCHA, JOSE CARLOS; FERRARESI, CLEBER; HAMBLIN, MICHAEL R.; MAIA, FLAVIO DAMASCENO; FALCAO DO NASCIMENTO, NILBERTO ROBSON; DRIUSSO, PATRICIA; PARIZOTTO, NIVALDO ANTONIO. Low-level laser therapy (904 nm) can increase collagen and reduce oxidative and nitrosative stress in diabetic wounded mouse skin. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 164, p. 96-102, . (10/07194-7)

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