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Fatty acids and diabetes as modulators of inflammatory phase of wound healing process

Grant number: 11/02234-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2011
Effective date (End): November 30, 2012
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Rui Curi
Grantee:Hosana Gomes Rodrigues
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:10/02963-2 - Modulation of inflammation and insulin resistance by omega-3 fatty acids and palmitoleate, AP.TEM

Abstract

In 2004 was developed by Prof. Jiang X. Kang, a strain of transgenic mice (FAT-1) that endogenously produce omega-3 (n-3) fatty acids from omega-6 (n-6) consumed in the diet. Through genetic manipulation, these animals began to express the enzyme delta-3 desaturase, which is responsible for converting fatty acids n-6 to n-3. The n-6/n-3 ratio has been determined in many tissues such as muscle, heart, liver, spleen, brain, and is considerably lower in FAT-1 mice compared to wild-type. These animals are being used to study the effects of n-3 fatty acids in various pathological conditions such as type II diabetes, colitis, hepatitis, pancreatitis and cancer. In this project, the process of wound healing will be investigated in mice FAT-1. We will analyze temporally the concentration of cytokines, growth factors, the content of eicosanoids and reactive oxygen species, activation of transcription factor (PPAR-³), angiogenesis, and activation of signaling pathways such as the mTOR at wound site.