The theory of diseases generated by inflammatory cytokines brought over the years evidence that the body may produce through cytokine biological or detrimental responses. In the mid-19th century, Rudolf Virchow suggested a possible association between inflammation and development of diseases. Thus, believed that inflammation is a key mechanism in the pathogenesis of some diseases such as obesity and cancer. Currently, is well established that obesity is associated with a state of subclinical chronic inflammation (low grade) and the cancer is associated with a severe inflammation. Recently, several studies suggest that hypothalamic AMPK, an enzyme important in the control of energy homeostasis is also responsible for modulating inflammation. A previous study from our laboratory showed that the activation of hypothalamic AMPK triggers a central and systemic anti-inflammatory action. However, only in vitro studies with macrophages and endothelial cells shows evidences that inhibition or deletion of AMPK increases inflammation. Thus, the main objective of the study is to evaluate the role of inhibition of hypothalamic AMPK in the development of central and systemic inflammation in models of obesity and cancer. Likewise, we believe that this project will contribute to a better understanding of how the hypothalamic and systemic inflammation can be modulated by hypothalamic AMPK.
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