Natural antioxidants action in Saccharomyces cerevisiae parkinsonian model

• Grant number: 11/03583-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2011
• End date: July 31, 2013
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Mario Henrique de Barros
• Grantee: Mariana Alba Zampol
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Parkinson disease is a neurodegenerative pathology dependent on environmental and genetic components. Among its genetic features there is the SNCA gene, which encodes the pro-oxidant protein alpha-synuclein, whose accumulation leads to lipotoxicity and to oxidative stress in neurons, characterized by the increment of the free radical production by mitochondria. The yeast Saccharomyces cerevisiae is a useful model organism for studying the effects of genetic mutations related to several neurologic disturbances and encephalomyopathy, as for associated therapies. This work aims to study yeasts expressing SNCA gene variants as a Parkinson reliable model and the possible effects of the use of endogenous antioxidants, like melatonin. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZAMPOL, MARIANA A.; BARROS, MARIO H.. Melatonin improves survival and respiratory activity of yeast cells challenged by alpha-synuclein and menadione. YEAST, v. 35, n. 3, p. 281-290, MAR 2018. (11/07366-5, 11/03583-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ZAMPOL, Mariana Alba. Natural antioxidants action in a Saccharomyces cerevisiae parkinsonian model.. 2013. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.