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Effects of low level laser radiation with wavelengths of 660nm and 808nm on cartilage injury

Grant number: 11/04834-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2011
Effective date (End): December 31, 2012
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Paulo de Tarso Camillo de Carvalho
Grantee:Ana Carolina Araruna Alves
Host Institution: Universidade Nove de Julho (UNINOVE). Campus Memorial. São Paulo , SP, Brazil


Articular cartilage is a specialized connective tissue, and avascular aneural comprised exclusively of cells called chondrocytes and a large amount of extracellular matrix (ECM). The pathologies that involve injury to the cartilage tissue are often associated with a controversial topic that is the ability to repair articular cartilage. It was believed that the cartilage had little capacity to regenerate), but researchers say that this tissue is metabolically active and therefore have the capacity to regenerate itself. The repair of cartilage lesions is dynamic, consisting of several processes, including inflammation, cell proliferation and synthesis of the elements that constitute the extracellular matrix like collagen and elastic fibers reticular fibers, however, when compared with other tissues, articular cartilage repair process presents an often slow and inefficient. Experimental studies in vivo, in vitro and clinical studies have demonstrated the positive effects of photobiostimulation through low power laser on cell proliferation, increased microcirculation, neovascularization, stimulation of collagen production by fibroblasts and bone repair. However, when it comes to cartilage lesions the results are still preliminary and controversial. The results demonstrate that both the biostimulation as bioinibição appear to be related to the wavelength and the energy generated, so this research aims to analyze and compare the effects of low power laser radiation with wavelengths of 660nm and 808nm in cartilage lesions. This study includes the implementation of an experimental model of osteoarthritis - AO, using the induction papain. To identify the effects will be carried out analysis of cell proliferation of chondrocytes and chondroblasts by computerized histomorphometry, the effects of low power laser in the immunoreactivity of proteins of the ECM, represented by fibronectin, tenascin and by the type I collagen, and the effects of Low power laser on levels of interleukin 1 (IL-1²) and -6 (IL-6) and the cytokine tumor necrosis factor (TNF-±), obtained in joint lavage model of chondral injury.OuvirLer foneticamente (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARARUNA ALVES, ANA CAROLINA; VIEIRA, RODOLFO DE PAULA; PINTO LEAL-JUNIOR, ERNESTO CESAR; DOS SANTOS, SOLANGE ALMEIDA; LIGEIRO, ANA PAULA; ALBERTINI, REGIANE; SILVA JUNIOR, JOSE ANTONIO; CAMILLO DE CARVALHO, PAULO DE TARSO. Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. ARTHRITIS RESEARCH & THERAPY, v. 15, n. 5, . (11/04834-8)
DOS SANTOS, SOLANGE ALMEIDA; ARARUNA ALVES, ANA CAROLINA; PINTO LEAL-JUNIOR, ERNESTO CESAR; ALBERTINI, REGIANE; VIEIRA, RODOLFO DE PAULA; LIGEIRO, ANA PAULA; SILVA JUNIOR, JOSE ANTONIO; CAMILLO DE CARVALHO, PAULO DE TARSO. Comparative analysis of two low-level laser doses on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. Lasers in Medical Science, v. 29, n. 3, p. 1051-1058, . (10/52404-0, 11/04834-8)

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