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Study of the mechanisms of infection and transmission of hantaviruses in rodent reservoir Araraquara (Necromys lasiurus)

Grant number: 11/05067-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2011
Effective date (End): March 31, 2013
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Luiz Tadeu Moraes Figueiredo
Grantee:William Marciel de Souza
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Viruses of the genus hantavirus are members of the family Bunyaviridae. These viruses cause two serious diseases transmitted by rodents to humans: Hemorrhagic Fever with Renal Syndrome (HFRS) or Hantavirus Cardiovascular Pulmonary Syndrome (HCPS), which is characterized by respiratory distress, fever, pulmonary vascular leakage, shock and high mortality and is a very important problem of public health. Hantaviruses are spherical with a diameter of 73-150 nm, enveloped RNA genome with negative polarity trissegment, defined as small, medium and large, is wrapped by a nucleoprotein. Human infection is acquired by inhalation of aerosols containing excrement of rodents infected with hantavirus, and its possible relationship, the increase of rodents, reservoirs in urban and peri-urban areas due to deforestation. The hantavirus have close association with its rodent reservoirs, and are commonly species-specific, on the American continent is more than 20 different species in hantavirus-rodent reservoirs. Recently, it was isolated in the region of Ribeirão Preto, the first hantavirus in Brazil, the etiologic agent of HCPS, the Araraquara virus (ARAV). ARAV has as the wild rodent reservoir Necromys lasiurus. Thus, this work aimed to study mechanisms of infection and virus excretion of ARAV from rodent-tanks aimed to understand aspects of infection and immune response of the ARAV. Thus, we intend to determine the best dose and route of excretion infection, infective viability of biological samples, physiological and immunological responses. In addition, studies of transmission among rodents, reservoirs also will be conducted, may help to elucidate mechanisms of infection and maintenance of hantaviruses in nature. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE PADUA, MICHELLY; DE SOUZA, WILLIAM MARCIEL; LAURETTI, FLAVIO; FIGUEIREDO, LUIZ TADEU MORAES. Development of a novel plaque reduction neutralisation test for hantavirus infection. Memórias do Instituto Oswaldo Cruz, v. 110, n. 5, p. 624-628, . (08/50617-6, 11/16866-1, 12/24150-9, 11/05067-0)
WILLIAM MARCIEL DE SOUZA; ALEX MARTINS MACHADO; LUIZ TADEU MORAES FIGUEIREDO. Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents. Memórias do Instituto Oswaldo Cruz, v. 111, n. 6, p. 399-402, . (09/17518-7, 08/50617-6, 11/05067-0, 12/24150-9)
MACHADO, ALEX MARTINS; DE SOUZA, WILLIAM MARCIEL; DE PADUA, MICHELLY; DA SILVA RODRIGUES MACHADO, ALINE RAFAELA; MORAES FIGUEIREDO, LUIZ TADEU. Development of a One-Step SYBR Green I Real-Time RT-PCR Assay for the Detection and Quantitation of Araraquara and Rio Mamore Hantavirus. Viruses-Basel, v. 5, n. 9, p. 2272-2281, . (08/50617-6, 11/16866-1, 11/05067-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, William Marciel de. Evolutionary study of Hantavirus and development of a quantitative real time RT-PCR for detection of Araraquara virus. 2013. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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