Studies towards the potential application of Streptomyces in biocatalysis reactions

• Grant number: 11/14910-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2011
• End date: March 31, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Carlos Henrique Inacio Ramos
• Grantee: Lucas Henrique Colombo
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Microorganisms, plants and animals produce a wide range of compounds that cold act as drugs, pigments, fragrances, flavorings and cosmetics. The biosynthesis of such metabolites is mediated by multienzymes complexes acting since the carbonic chain extension to the post-modifying steps. The versatility of such enzymes could be applicable to bioconversions of xenobiotics in order to obtain chiral blocks. We intend to study in this project the capacity of strptomyces strains to promote biotransformations mediated by monooxigenases, oxido-reductases and hydrolysis using whole cell systems. (AU)