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Effects of omega-3 supplementation in inflammatory, lipid and oxidative parameters in hemodialysis patients

Grant number: 11/13756-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2011
Effective date (End): September 30, 2014
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Paula Garcia Chiarello
Grantee:Andresa Marques de Mattos
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The population on hemodialysis (HD) is vulnerable to several complications, such as uremic dyslipidemia, chronic inflammation and increased oxidative stress (OS), which negatively affect the time and quality of life for these patients. In recent decades, new therapies were introduced for the purposes of improving the morbidity and mortality in this group, however, without much success. Based on laboratory data and preliminary clinical findings, there are reasons to suggest that omega-3 supplementation may provide health benefits of HD patients. Therefore, the aim of this study is clarify the effects of this supplementation on markers of OS, inflammation and dyslipidemia in this population. It is an experimental controlled randomized double-blind study, in which a group of patients treated for HD and one control group will be supplemented with 1.2g / d of omega-3 for 12 weeks, while the others two groups, one formed by HD patients and other by healthy controls will receive placebo. Blood samples to perform the biochemical evaluation will be conducted at baseline, sixth and twelfth week. The nutritional status of individuals from four groups will be assessed by anthropometry, body composition and food consumption at the beginning and the end of the intervention (AU)