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Inhibition effects of aurora-kinase in cell lines of pediatric medulloblastoma

Grant number: 11/15645-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2011
Effective date (End): October 31, 2013
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Luiz Gonzaga Tone
Grantee:Lenisa Geron
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Medulloblastoma (MB) is a central nervous system (CNS) neoplasm that occurs more frequently in children but may occur in adolescents and young adults. It is regarded as a variant of primitive neuroectodermal tumors (PNETs), derived from immature neurons remaining external granular layer, present in the cerebellum. According to the World Health Organization (WHO) these tumors are subdivided into five variants: classic medulloblastoma, desmoplasic/nodular medulloblastoma, and medulloblastoma with extensive nodularity (MBEN), anaplasic medulloblastoma and large cells medulloblastoma. The classic form is the most frequent, representing about 80% of cases. Current treatment is based on the maximum surgical removal, followed by local radiation and craniospinal and/or chemotherapy. Despite aggressive multimodal therapy, the spread of the disease is common and a significant proportion of medulloblastomas have proved largely refractory. In recent years, many advances have collaborated with the identification of new therapeutic targets. Among these, the Aurora-kinases family, which comprises three homologous serine/threonine kinases, Aurora-A, B, and C, have been widely studied in various tumors. These genes act in various cell cycles processes such as centrosome maturation, spindle mitotic organization, and anchoring of spindle protein in the kinetochore of the chromosomes. In different types of neoplasias, two members of this family, Aurora-A and Aurora-B, have been found overexpressed, for this reason, it is believed they play an important role in the establishment of cancer. The aim of this work is to investigate the effects of pharmacological inhibition of these proteins in cell lines of pediatric medulloblastoma.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GERON, LENISA; BORGES, KLEITON SILVA; ANDRADE, AUGUSTO FARIA; SUAZO, VERIDIANA KILL; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Antitumour activity of AMG 900 alone or in combination with histone deacetylase inhibitor SaHa on medulloblastoma cell lines. NEUROLOGICAL RESEARCH, v. 37, n. 8, p. 703-711, . (11/15645-1)

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