Ureasil-Polieter hybrid film forming for skin protection and controlled drug delivery

• Grant number: 11/21980-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2012
• End date: February 28, 2013
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Leila Aparecida Chiavacci Favorin
• Grantee: Letícia Moriya Shiota
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

There are many interests in new dosage forms intended to increase patient adherence to treatment. The hybrid polymer matrices are a great option for these new forms, possessing superior mechanical and optical properties as compared to conventional polymers. In addition, organic-inorganic hybrids present other typical characteristics that increase the patient adherence to the treatment, controlled drug release rate, and interesting occlusive properties. This work is related to the master thesis of Juliana Fernandes Mendes, financed by FAPESP (process 2010/03335-5) and is part of a project FAPESP (process n° 2011/01971-4) that has an objective to prepare film forming materials by using organic-inorganic hybrids to be used simultaneously as a skin protector, wound protector and drug delivery matrixes. The aim of this work is to verify the influence of different kinds of catalyst agents in the preparation of organic-inorganic hybrid film-forming matrixes and to establish the relationships between the chemical nature of the catalyst agent and the ability of the matrixes to incorporate and control the drug delivery profiles.(AU)