The action of bioactive peptides from amaranth grain (Amaranthus cruentus L. BRS Alegria) subjected to various thermal processes in the micellar solubilization of cholesterol

• Grant number: 10/14474-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2012
• End date: December 31, 2013
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: José Alfredo Gomes Arêas
• Grantee: Amanda Caroline Cardoso Corrêa Carlos Menezes
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Cardiovascular diseases account for the largest percentage of deaths in Brazil. There is a wide range of evidence pointing physiological factors such as obesity and dyslipidemia as major contributors to cardiovascular diseases and also indicate that consumption of vegetables, especially of their proteins, acts in the magnitude of these protective conditions. Among these proteins is the grain amaranth, whose cholesterol-lowering action has been consistently demonstrated, although it is not known so far, the mechanisms involved. One possibility is the action of peptides, originating from incomplete digestion of the protein of amaranth, which control the level of serum cholesterol, reducing its solubility in the intestinal lumen and its endogenous synthesis, lowering levels of atherogenic particles in the body. Amaranth is traditionally consumed after thermal processing. Thus, this study aims to determine possible changes in the micellar solubilization of cholesterol in vitro (the best indicator of its reduction of intestinal absorption) by peptides derived from the hydrolysis of amaranth grain protein previously subjected to various thermal processes: popped, toasted and extruded.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MENEZES, Amanda Caroline Cardoso Corrêa Carlos. Effect of amaranth grain (Amaranthus cruentus L.) processed protein hydrolyzate in the micellar solubilization of cholesterol and inhibition of HMGR. 2013. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.