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Effect of type I interferon in the induction of tolerogenic function of plasmacytoid dendritic cells in experimental autoimmune encephalomyelitis

Grant number: 11/15639-1
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal researcher:Leonilda Maria Barbosa dos Santos
Grantee:Mariana Peres Almeida Santos
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The type I interferon is commonly used in the treatment of multiple sclerosis. However, some effects of this cytokine still remain to be elucidated. The plasmacytoid dendritic cells when activated with TLR 9 agonist produced significant amount of type I interferon and indoleamina 2,3 dioxigenase (IDO). This enzime contribute to the activation of regulatory T lymphocytes, which are impaired in multiple sclerosis in relapse. Here, our aim is to study the effect of administration of IFN beta on function of plasmacytoid dendritic cells of mice with experimental autoimmune encephalomyelitis (EAE). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORAES, ADRIEL S.; PAULA, ROSEMEIRE F. O.; PRADELLA, FERNANDO; SANTOS, MARIANA P. A.; OLIVEIRA, ELAINE C.; VON GLEHN, FELIPE; CAMILO, DANIELA S.; CERAGIOLI, HELDER; PETERLEVITZ, ALFREDO; BARANAUSKAS, VITOR; VOLPINI, WALKYRIA; FARIAS, ALESSANDRO S.; SANTOS, LEONILDA M. B. The Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells Induced by Multiwalled Carbon Nanotubes Reduces the Severity of Experimental Autoimmune Encephalomyelitis. CNS Neuroscience & Therapeutics, v. 19, n. 9, p. 682-687, SEP 2013. Web of Science Citations: 12.
FARIAS, ALESSANDRO S.; SPAGNOL, GABRIELA S.; BORDEAUX-REGO, PEDRO; OLIVEIRA, CAMILA O. F.; FONTANA, ANA GABRIELA M.; DE PAULA, ROSEMEIRE F. O.; SANTOS, MARIANA P. A.; PRADELLA, FERNANDO; MORAES, ADRIEL S.; OLIVEIRA, ELAINE C.; LONGHINI, ANA LEDA F.; REZENDE, ALEXANDRE C. S.; VAISBERG, MAURO W.; SANTOS, LEONILDA M. B. Vitamin D-3 Induces IDO+ Tolerogenic DCs and Enhances Treg, Reducing the Severity of EAE. CNS Neuroscience & Therapeutics, v. 19, n. 4, p. 269-277, APR 2013. Web of Science Citations: 72.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Mariana Peres Almeida. Effect of type I interferon induction of tolerogenic function of plasmacytoid dendritic cells in experimental autoimmune encephalomyelitis. 2014. Master's Dissertation - Universidade Estadual de Campinas. Instituto de Biologia.

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