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Enantioselective synthesis of functionalized piperidines through penta-components reaction, using Niobium compounds as catalysts

Grant number: 11/14769-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Luiz Carlos da Silva Filho
Grantee:Lucas Michelão Martins
Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


In this project we propose to study the application of niobium compounds in multicomponents reactions, verifying in details the effect of temperature and molar concentration of these reactants on those reactions. The comparisons of the yields and the reaction time of the niobium compounds used with other reactants will also be a fundamental point in the research.The reactions we propose to study in this work are the reactions for the preparation of functionalized piperidines, abundant compounds in nature and that present a great farmacological interest, having applications as anti-hypertensive, antibacterial, anticonvulsing and anti-inflammatory drugs. We propose in this project the using of different Niobium compounds to obtain this derivatives, through the reaction between derivatives of aniline, benzaldehyde and ²-keto-ésters. The Niobium compounds that are targets of our study are: Nb(OEt)5 and its chiral derivatives, using different chiral terpenic alcohols as enantioselective helpers.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NARANJO-MONTOYA, OSCAR A.; MARTINS, LUCAS M.; DA SILVA-FILHO, LUIZ C.; BATAGIN-NETO, AUGUSTO; LAVARDA, FRANCISCO C.. The Correlation Between Electronic Structure and Antimalarial Activity of Tetrahydropyridines. Journal of the Brazilian Chemical Society, v. 26, n. 2, p. 255-265, . (13/08697-0, 10/18022-2, 11/14769-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARTINS, Lucas Michelão. Estudos sobre a síntese de piperidinas funcionalizadas através de reações pentacomponentes, utilizando compostos de nióbio como catalisadores. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências. Bauru Bauru.

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