Mechanisms associated with the development of complications of type 2 diabetes in female mice ob/ ob: preventive role of physical training aerobic dynamic, resistance or combined

• Grant number: 11/20859-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2012
• End date: February 28, 2015
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Maria Claudia Costa Irigoyen
• Grantee: Michelle Sartori
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The aim of this study is to evaluate the role of aerobic, resistance or combined (aerobic+resistance) exercise training in the development of type 2 diabetes, analyzing the mechanisms associated with diabetes complications in female mice with leptin production deficiency (ob/ob). For this purpose, 48 female mice, initially with 4 weeks of age, will be used and divided into six groups: sedentary wild type (SS), 4-week old ob/ob sedentary (OS-4), 12-week old ob/ob sedentary (OS-12), ob/ob aerobic training (OAT), ob/ob resistance training (ORT) and ob/ob combined training (OCT). The trained groups will undergo eight weeks of dynamic aerobic exercise training on a treadmill (50 to 60% of the maximum speed of the exercise test) or resistance ladder climb (40-60% of maximum load) or the combination of the two training sessions (combined). At the end of the protocol (four weeks for group OS-4 and 12 weeks for the other groups) it will be evaluated: body weight; blood glucose, triglycerides and cholesterol; blood pressure and heart rate; baroreflex sensitivity; cardiovascular autonomic modulation; oxidative stress parameters; and hormonal and inflammatory markers. Our results may contribute to the understanding of the mechanisms responsible for the development of diabetes in women, as well as enable to assess and compare the effects of aerobic, resistance or combined training, demonstrating the importance of physical activity in preventing disorders associated with diabetes.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SARTORI, Michelle. Mechanisms associated with the development of complications of type 2 diabetes in ob/ob female mice: preventive role of dynamic aerobic resistance or combined exercise training. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.