Isolation, identification and mechanism of action of fractions and active principles of Boehmeria caudata Sw with anticancer activity.

• Grant number: 11/22458-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2012
• End date: February 29, 2016
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: João Ernesto de Carvalho
• Grantee: Paula Pereira de Paiva
• Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil

Abstract

Cancer is the second cause of death in developed and developing countries. The progressive increasing of case number makes clear the need of continuous development of new chemotherapeutic. About 60% of anticancer drugs are derived from natural products, demonstrating the great potential of these products in research and development of new anticancer drugs. Thus, based on a project BIOPROSPECTA - FAPESP which aimed the evaluation of antiproliferative activity of medicinal plants used by population of a protected area of Serra da Mantiqueira Paulista, a master's degrees project was developed in order to evaluate two species of Boehmeria genus. Between these two species, the ethanolic extract of B. caudata showed the best antiproliferative activity profile for most human tumor lines studied, with cytotoxic effects at concentrations in the order of 0.25 µg/mL. Moreover, from this extract, a mixture of alkaloids was isolated which presented a very good antiproliferative profile in vitro. Based on these results, this project aims to continuing B. caudata antiproliferative evaluation by isolation of active compounds, evaluation of its anticancer activity in vivo and determination of their possible mechanism of action.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE PAIVA, PAULA P.; NUNES, JULIA H. B.; NONATO, FABIANA R.; RUIZ, ANA L. T. G.; ZAFRED, RAFAEL R. T.; SOUSA, ILZA M. O.; OKUBO, MARCIA Y.; KAWANO, DANIEL F.; MONTEIRO, PAULA A.; FOGLIO, MARY A.; et al. In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained fromBoehmeria caudataSw. Aerial Parts. Molecules, v. 25, n. 17, SEP 2020. (17/21801-2, 12/19661-4, 11/22458-3, 14/06636-7, 11/22457-7)

DE PAIVA, PAULA P.; NUNES, JULIA H. B.; NONATO, FABIANA R.; RUIZ, ANA L. T. G.; ZAFRED, RAFAEL R. T.; SOUSA, ILZA M. O.; OKUBO, MARCIA Y.; KAWANO, DANIEL F.; MONTEIRO, PAULA A.; FOGLIO, MARY A.; et al. In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained fromBoehmeria caudataSw. Aerial Parts. Molecules, v. 25, n. 17, p. 20-pg., 2020-09-01. (12/19661-4, 17/21801-2, 11/22457-7, 11/22458-3, 14/06636-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PAIVA, Paula Pereira de. Evaluation of antitumor and anti-inflammatory activity of phenanthroquinolizidines alkaloids rich fraction of Boehmeria caudata Sw.. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.