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Evaluation of transcription factors that induce ephitelial-mesenchymal transition (EMT) in endothelial cell biology

Grant number: 11/21740-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): July 31, 2015
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Simone Kashima Haddad
Grantee:Mariana Tomazini Pinto
Home Institution: Hemocentro de Ribeirão Preto. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Secretaria da Saúde (São Paulo - Estado). Ribeirão Preto , SP, Brazil

Abstract

The Endothelial Mesenchymal Transition (EndMT) is categorized as a specialized form of Epithelial Mesenchymal transition (EMT), in which endothelial cells (CEs) lose intracellular junctions and endothelial markers, acquire mesenchyal phenotype, as well as invasive and migratory functions. In physiological condition, the EndMT is envolved in embryogenesis and in the origin and maintenance of mesenchymal stem cells (MSCs) in the adult organism. In pathological condition, the EndMT is responsible for the fibrosis formation and participates in tumor progression. Regarding the mechanisms of induction of EndMT, it is postulated that EMT and EndMT share the same molecular mechanisms. Several transcription factors are related to the induction and regulation of EMT. Thus, the objective of this study is to investigate EndMT process in CEs of different sources. For this purpose, transcription factors associated with EMT will be overexpressed in CEs and EndMT will be evaluated. Additionally, we will analyze which molecular factors are involved in this process. Understanding these mechanisms will allow a better understanding of CEs biology, as well as the EndMT function in the stem cell generation. Moreover, this study will contribute to new knowledge and development of new therapeutic approaches using cell therapy. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PINTO, MARIANA TOMAZINI; FERREIRA MELO, FERNANDA URSOLI; MALTA, TATHIANE MAISTRO; RODRIGUES, EVANDRA STRAZZA; PLACA, JESSICA RODRIGUES; JR SILVA, WILSON ARAUJO; PANEPUCCI, RODRIGO ALEXANDRE; COVAS, DIMAS TADEU; RODRIGUES, CLAUDIA DE OLIVEIRA; KASHIMA, SIMONE. Endothelial cells from different anatomical origin have distinct responses during SNAIL/TGF-beta 2-mediated endothelial-mesenchymal transition. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, v. 10, n. 12, p. 4065-4081, 2018. Web of Science Citations: 1.
PINTO, MARIANA T.; COVAS, DIMAS T.; KASHIMA, SIMONE; RODRIGUES, CLAUDIA O. Endothelial Mesenchymal Transition: Comparative Analysis of Different Induction Methods. BIOLOGICAL PROCEDURES ONLINE, v. 18, APR 27 2016. Web of Science Citations: 14.
PINTO, MARIANA TOMAZINI; MALTA, TATHIANE MAISTRO; RODRIGUES, EVANDRA STRAZZA; PINHEIRO, DANIEL GUARIZ; PANEPUCCI, RODRIGO ALEXANDRE; RIBEIRO MALMEGRIM DE FARIAS, KELEN CRISTINA; SOUSA, ALESSANDRA DE PAULA; TAKAYANAGUI, OSVALDO MASSAITI; TANAKA, YUETSU; COVAS, DIMAS TADEU; KASHIMA, SIMONE. Genes Related to Antiviral Activity, Cell Migration, and Lysis Are Differentially Expressed in CD4(+) T Cells in Human T Cell Leukemia Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Patients. AIDS Research and Human Retroviruses, v. 30, n. 6, p. 610-622, JUN 2014. Web of Science Citations: 4.

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