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Effects of maternal food restriction on nephrogenesis: morphological and moleculars aspects

Grant number: 11/23508-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2012
Effective date (End): August 31, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Flávia Mesquita Vieira
Grantee:Carmen Maria das Graças Grigoletti Mir
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

One of the consequences of the maternal food restriction is the incorrect fetal development. The Fetal Programming hypothesis has been studied largely, suggesting adaptation on fetus which mother suffered with undernutrition during the pregnancy. Recent studies have been showing that maternal protein restriction leads to a hypertensive status, with changes in kidney function due to an impaired nephrogenesis. Even with many studies, the relation between total food privation and nephrogenesis must be searched. The aim of this project is to investigate the effects of food restriction during gestational period on kidney development on male rats, studying the ureteric branching by metanephroi culture, and to quantify the glomerular number. Thus, it's aimed to study the mRNA that regulate the kidney development. (AU)

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