Effects of maternal food restriction on nephrogenesis: morphological and moleculars aspects

• Grant number: 11/23508-4
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): March 01, 2012
• Effective date (End): August 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal researcher: Flávia Mesquita Vieira
• Grantee: Carmen Maria das Graças Grigoletti Mir
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

One of the consequences of the maternal food restriction is the incorrect fetal development. The Fetal Programming hypothesis has been studied largely, suggesting adaptation on fetus which mother suffered with undernutrition during the pregnancy. Recent studies have been showing that maternal protein restriction leads to a hypertensive status, with changes in kidney function due to an impaired nephrogenesis. Even with many studies, the relation between total food privation and nephrogenesis must be searched. The aim of this project is to investigate the effects of food restriction during gestational period on kidney development on male rats, studying the ureteric branching by metanephroi culture, and to quantify the glomerular number. Thus, it's aimed to study the mRNA that regulate the kidney development. (AU)