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Comparative study of the effects of protein restriction in utero and dexamethasone in vitro exposure during nephrogenesis: assessment of gene expression, of miRNAs, protein, and morphometric in metanephric mesenchyme

Grant number: 12/18492-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2014
Effective date (End): June 01, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Patrícia Aline Boer
Grantee:Letícia de Barros Sene
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):15/15148-9 - MicroRNAs expression profile and reconstruction of gene regulatory networks involved in different periods of renal ontogenesis of animals that suffered gestational protein restriction, BE.EP.DR

Abstract

Both the protein-calorie malnutrition and hypertension represent global problems of public health. Epidemiologic studies in populations, as well as experimental results indicate that intrauterine nutritional conditions "program" the development of hypertension and coronary heart disease in adults. From these results has been showed that protein deprivation during pregnancy, an active period of nephrogenesis, causes reduction in the glomeruli number at birth. Thus, the predisposition to hypertension can be determined at least in part, by abnormal development of kidney. One of the factors involved in the genesis of fetal programming is the increased fetus exposure to maternal glucocorticoids. However it is not known whether this mechanism is also involved and undertakes the process of nephrogenesis. Recent studies show that the number of mesenchymal cap (CM) stem cells, around the edge of the shoot of the ureter, determines the final number of nephrons. The objectives of this project are: 1) assess the CM area and the rates of cells death and proliferation in CM, 2) gene and miRNAs expression; 3) number of positive cells for proteins controlling cell cycle, Bim protein and stem cells markers in the CM of the offspring of rats subjected to protein restriction during pregnancy, compared to their controls, at different periods of renal ontogenesis. Will also be checked the same parameters in cultured metanefros exposed to dexamethasone (DEX) mimicking fetal corticosteroids high concentration that has been verified in the gestational protein restriction models. The studies aim to associate both morphometric profile and gene expression to the nephron reduction observed in this model.

News published in Agência FAPESP Newsletter about the scholarship:
Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole 
Una dieta hipoproteica en la gestación puede causar problemas renales en la prole, según um estudio  
Study shows how low-protein intake during pregnancy can cause renal problems in offspring 
Articles published in other media outlets (49 total):
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UOL: Dieta pobre em proteína na gestação pode causar problemas renais na prole (24/Mar/2021)
SLNdoors: Study shows how low-protein intake during pregnancy can cause renal problems in offspring (15/May/2021)
AapKe News (Índia): अध्ययन से पता चलता है कि गर्भावस्था के दौरान कम प्रोटीन का सेवन बच्चे में गुर्दे की समस्याओं का कारण बन सकता है (07/May/2021)
Ani News - South Asia's Leading Multimedia News Agency (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in child (06/May/2021)
M3 India (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in child (06/May/2021)
DT Next (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in child (06/May/2021)
The Uncover Reality (Índia): Study Shows How Low-protein Intake During Pregnancy Can Cause Renal Problems in Offspring (Medicine) (06/May/2021)
The Fact News (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in child (06/May/2021)
News O Time (Estados Unidos): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (06/May/2021)
Newscon: Researchers show how low-protein diet during pregnancy can cause kidney problems in babies (06/May/2021)
Detonic: Изследователско проучване показва как ниската консумация на протеини по време на бременност може да създаде проблеми с бъбреците при деца (06/May/2021)
AapKe News (Índia): अध्ययन से पता चलता है कि गर्भावस्था के दौरान कम प्रोटीन का सेवन बच्चे में गुर्दे की समस्याओं का कारण बन सकता है (06/May/2021)
Doctorsconscience.org: Study shows how low-protein intake during pregnancy can cause renal problems in offspring (06/May/2021)
Inter Reviewed: Study shows how low-protein intake during pregnancy can cause renal problems in offspring (06/May/2021)
News Medical (Austrália): Researchers show how low-protein diet during pregnancy can cause kidney problems in babies (05/May/2021)
Medical Xpress (Reino Unido): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
Bioengineer (Reino Unido): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
Science Codex: Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
Scienmag Science Magazine (Reino Unido): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
InfoSurHoy (EUA): Study shows how low-protein intake during pregnancy can cause renal problems in offspring. (05/May/2021)
Sify (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in child (05/May/2021)
Yahoo! (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in child (05/May/2021)
Medicine Ball-Exercises: Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
News Break (EUA): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
Burada Biliyorum (Turquia): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
Zephyrnet.com (EUA): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
Erwotex.net: Researchers show how low-protein diet during pregnancy can cause kidney problems in babies (05/May/2021)
Oullins-Patriote.com: Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
ZEE5 (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in child (05/May/2021)
Goalshakers (Reino Unido): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
Biotech Asia News (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
MediExpose (ìndia): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
4State News: Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
The Health News Express: Study reveals how low-protein consumption throughout being pregnant may cause renal issues in offspring (05/May/2021)
Beyond Fitness Forever: Researchers show how low-protein diet during pregnancy can cause kidney problems in babies (05/May/2021)
NewsLife247 (Índia): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (05/May/2021)
163.com (China): Study shows how low-protein intake during pregnancy can cause renal problems in offspring (01/May/2021)
Jornal de Piracicaba online: Falta de proteína em dietas para gestantes pode causar doenças renais nos filhos (01/Apr/2021)
Plantão News (MT): Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole (29/Mar/2021)
Espaço Ecológico no Ar: Dieta pobre em proteína na gestação pode causar problemas renais na prole (28/Mar/2021)
Blog Jornal da Mulher: Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole (25/Mar/2021)
Saense: Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole (25/Mar/2021)
Programa InfoSalud (Argentina): Un estudio demuestra cómo una dieta pobre en proteínas durante la gestación puede causar problemas en la descendencia (25/Mar/2021)
Revista Amazônia: Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole (24/Mar/2021)
Compre Rural: Dieta sem carne da mãe causa sérios danos à saúde do bebê (24/Mar/2021)
Portal da Enfermagem: Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole (24/Mar/2021)
Novo Cantu Notícias: Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole (24/Mar/2021)
Coluna Supinando: Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole (24/Mar/2021)
Quimiweb: Estudo mostra como dieta pobre em proteína durante a gestação pode causar problemas renais na prole (24/Mar/2021)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SENE, Letícia de Barros. Expressão de mRNAs, miRNAS e proteínas reguladoras da nefrogênese em ratos programados por restrição proteica in utero. 2016. 156 f. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu)..

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