| Grant number: | 12/01444-7 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | May 01, 2012 |
| End date: | April 30, 2016 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Luiz Roberto Giorgetti de Britto |
| Grantee: | Katherine Garcia Ravelli |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Alzheimer's disease (AD) is characterized by a progressive loss of memory, disordered cognitive function, language decline, and behavioral changes such as paranoia and delirium. The neurodegeneration found in AD patients has been frequently associated to oxidative damage. Some studies suggested the involvement of NADPH oxidase in the pathophysiology of neurodegenerative diseases such as AD. However, the mechanisms involved in its activation, expression and regulation are still unclear. In the present study we intend to investigate the possible involvement of NADPH oxidase in inflammation, neurodegeneration and neurogenesis in regions typically affected in AD pathogenesis, namely hippocampus and amygdala. In order to induce AD, streptozotocin will be injected into the lateral ventricles of both Wt and Gp91phox deficient mice. Immunohistochemical and immunoblotting procedures, real-time polymerase chain reaction, Fluoro-Jade B, TUNEL assays and behavioral tests will be combined in order to evaluate NADPH oxidase involvement in the streptozotocin-induced AD mice model. (AU) | |
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